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Top 10 Global CDMO Enterprises| The Meaning of IND, NDA and ANDA| Top 10 Global Clinical Research Organizations in 2021
Sep 08,2016
Gene Therapy for Sickle Cell Aces Vital Preclinical Test
    Sickle-cell disease falls into an intriguing scientific paradigm—it is very well studied from multiple scientific angles and most of the molecular mechanisms associated with the disease have been elucidated. However, treatments for the disease have been lacking, as there are very few ways to combat the genetic disorder, without rectifying the DNA mutation that causesRead more
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Sep 08,2016
Medicilon's Lead Optimization in Drug Discovery
Medicilon's medicinal chemistry involves the application of a number of specialized disciplinary approaches all focused on the ultimate goal of drug discovery.  Drug target identification and validation, rational (target-based) drug design, structural biology, computational-based drug design, methods development (chemical, biochemical and computational), and "Hit-to-lead” development are all aspects of medicinal chemistry.  The techniques and approachesRead more
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Medicilon's Lead Optimization in Drug Discovery
Sep 07,2016
Flesh Eating Bacteria Vaccine Could Be around the Corner
    Few things will conjure up innate fears more than tiny drug-resistant microorganisms steadily feasting on human tissue, with amputation often being the only recourse for survival. The bacteria that cause necrotizing fasciitis, or "flesh-eating disease”—group A Streptococcus (group A Strep)—is highly infectious and leads to more than 500,000 deaths per year.     Now, biochemists at theRead more
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Flesh Eating Bacteria Vaccine Could Be around the Corner
Sep 07,2016
Novel Approaches Target Esophageal Cancer
    Researchers say they have discovered that esophageal cancer can be classified into three different subtypes, paving the way for testing targeted treatments tailored to patients' disease for the first time.     Their study ("Mutational Signatures in Esophageal Adenocarcinoma Reveal Etiologically Distinct Subgroups with Therapeutic Relevance”), published in Nature Genetics, could help find drugs that target specific weaknesses inRead more
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Novel Approaches Target Esophageal Cancer
Sep 07,2016
Preclinical Drug Safety Ealuation and Drug Safety Testing
The preclinical services that Medicilon offers focus on preclinical pharmacokinetic and drug safety assessment (evaluation) for foreign and domestic clients.     Preclinical Drug Safety Testing : In vitro and in vivo testing to determine if the drug is safe enough for human testing. OUR SERVICES: Single dose toxicity test (rodent and non-rodent) Repeated dose toxicityRead more
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Preclinical Drug Safety Ealuation and Drug Safety Testing
Sep 06,2016
New Technique Improves Analysis of Mitochondrial Dysfunction
    Researchers at the Whitehead Institute say they have developed a method to isolate quickly and systematically measure metabolite concentrations within mitochondria.  Prior attempts at such measurements have yielded unreliable results, either by taking too long to isolate mitochondria or by contaminating mitochondrial metabolites with contents from other cellular components, according to the scientists.       "TheRead more
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New Technique Improves Analysis of Mitochondrial Dysfunction
Sep 06,2016
That Old Cell Line Just Are Not What It Used to Be
    The use of in vitro-cultured cells within the life sciences is an indispensable tool for a variety of fundamental assays. Yet periodically, cell lines need to be analyzed genetically to make certain that they are not only still representative of the cells from which they were derived—as cultured cells can drift genetically over time—but moreRead more
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That Old Cell Line Just Are Not What It Used to Be
Sep 05,2016
War on Cancer May Shift to Containment Strategy
The war on cancer may become a cold war, now that a new drug-delivery system has shown that it is possible to combine careful targeting with small, frequent dosing. With such a system, it may be possible to avoid the usual rollback approach, the administration of "maximum tolerable doses” of chemotherapeutic drugs. Because all-out hostilitiesRead more
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War on Cancer May Shift to Containment Strategy
Sep 05,2016
Cancer and Unstable Genomes Linked to Junk DNA Changes
    Researchers have long known that all humans are 99.9% identical, genetically speaking. But that tiny 0.1% variation has big consequences, influencing the color of your eyes, the span of your hips, and your risk of getting sick.     Although variants are scattered throughout the genome, scientists have largely ignored the stretches of repetitive genetic code onceRead more
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Cancer and Unstable Genomes Linked to Junk DNA Changes
Sep 02,2016
Vitamin C May Boost to Help Treat Leukemia
Interestingly, a pilot clinical trial based on this work is currently ongoing in adult patients with myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) at Rigshospitalet in Copenhagen, Denmark. This trial combines a similar drug called azacitidine—the standard of care therapy—with vitamin C.
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Vitamin C May Boost to Help Treat Leukemia