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Top 10 Global CDMO Enterprises| The Meaning of IND, NDA and ANDA| Top 10 Global Clinical Research Organizations in 2021
Sep 26,2016
Cell Division the Outcome of an Adversarial Process
Two mutually antagonistic protein complexes have been found to duel on the precipice of cell division. Whichever one prevails determines whether the cell remains in the G1 phase (where the focus is on growth) or enters the S phase (where the focus is on chromosome duplication and separation). It has long been known that oneRead more
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Sep 26,2016
Fluorescent In Situ Hybridization (Fish) Services
Medicilon offers a full line of Fluorescence in situ Hybridization (FISH) services, from standardized testing of validated assays to custom development of new assays. Drawing on many years of experience and in-depth knowledge, we guarantee that you will get the best FISH services from us for the ultimate success of your scientific research. FISH, alsoRead more
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Fluorescent In Situ Hybridization (Fish) Services
Sep 23,2016
Ion Channel Screening Services
Ion Channel Screening Service Medicilon provides a wide range of ion channel assays to quickly and accurately provide results for drug discovery and development research worldwide. We offer ion channel screening services on a variety of different high quality electrophysiology platforms. These services include: Compound Screening  Our screening compound system allows chemists and compound managersRead more
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Ion Channel Screening Services
Sep 23,2016
Unpriming Bacterial Pumps to Block Antibiotic Resistance
    When a bacterial machine called the efflux pump is in working order, it expels antibiotics, contributing to antibiotic resistance. The pump, however, cannot work if it lacks all of its molecule-sized parts. Keeping these parts out of stock, then, is a promising strategy in preserving the effectiveness of antibiotics that qualify as "last line ofRead more
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Unpriming Bacterial Pumps to Block Antibiotic Resistance
Sep 23,2016
New Protein Target Offers Hope for Crohn Sufferers
    Researchers from the Sanford Burnham Prebys Medical Discovery Institute (SBP) identified a promising new target for future drugs to treat inflammatory bowel disease (IBD). Their study ("Control of Paneth Cell Fate, Intestinal Inflammation, and Tumorigenesis by PKCλ/ι”), published in Cell Reports, also indicates that another protein, protein kinase C (PKC) λ/ι, may serve as aRead more
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New Protein Target Offers Hope for Crohn Sufferers
Sep 22,2016
Immunotherapy Boosted by Discovery of Molecular Switch
Exploiting the body's immune system to fight progressive pathological conditions such as cancer, Crohn's, and Alzheimer's is the basis for novel immunotherapy compounds that are beginning to take the drug market by storm. While various immunotherapy regimens have met with excellent results, not every patient has had an efficacious response.
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Immunotherapy Boosted by Discovery of Molecular Switch
Sep 22,2016
Novel Cancer Therapy Attacks Fatty Acid Synthesis in Cells
Scientists know that cells create their own fat molecules to build their plasma membranes and other critical structures. Now, researchers at the Salk Institute, along with academic and industry collaborators, have described a method ("Inhibition of Acetyl-CoA Carboxylase Suppresses Fatty Acid Synthesis and Tumor Growth of Non-Small-Cell Lung Cancer in Preclinical Models") in Nature Medicine
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Novel Cancer Therapy Attacks Fatty Acid Synthesis in Cells
Sep 22,2016
Medicilon's Yeast Two Hybrid Services
The yeast "two hybrid” or "interaction trap” assay, is a technique used to study protein-protein interactions, which are critical in virtually all cellular processes. The study of protein-protein interactions can be divided into three major parts: • Identification of binding proteins • Characterization of known interactions • Potential to manipulate such interactions This technology isRead more
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Medicilon's Yeast Two Hybrid Services
Sep 21,2016
Pathogenic Gut Microbes Flourish in Wake of Tissue Repair Response
    In an effort to understand the mechanisms governing pathogenic gut bacteria better, researchers at the University of California Davis, School of Medicine inquired why some food-borne bacteria cause severe illness. In the results from their recently published study, the investigators describe how pathogens in the intestinal tract cause harm by benefiting from immune system responsesRead more
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Sep 21,2016
Snail Insulin Faster Than Human Insulin
    Slow and steady may not always win the race, not when an insulin injection is needed to control diabetes. Although fast-acting synthetic versions of human insulin have been available since 1996, they may not be fast enough, taking 15 to 30 minutes to become effective. An even faster version of insulin, however, may be gainingRead more
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Snail Insulin Faster Than Human Insulin