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Top 10 Global CDMO Enterprises| The Meaning of IND, NDA and ANDA| Top 10 Global Clinical Research Organizations in 2021
Nov 16,2016
How the Immune System Keeps ‘Traitor Cells’ in Lockdown
    New Australian research has shown how the immune system avoids attacking its own tissues with antibodies — whilst still maintaining a strong defense against invaders. The findings, from the Garvan Institute of Medical Research (Sydney) and the John Curtin School of Medical Research (Australian National University), have just been published in the leading journal NatureRead more
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Nov 16,2016
"Acne Bacteria” Integral Part of Skin Microbiota Defense System
    It's probably difficult for teenagers to imagine that bacteria on their skin—often the ones involved in acne breakouts—are critical to the primary defense of our bodies from much more pathologic microbes. Yet, that is exactly what investigators at Lund University in Sweden recently discovered in a new research study, which describes that the most commonRead more
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Nov 15,2016
Genetic Mutations Found That Distinguish Aggressive Meningiomas from Benign Forms
    Scientists from Brigham and Women’s Hospital (BWH), in collaboration with colleagues at Massachusetts General Hospital, have identified genetic mutations in the form of brain cancer known as meningioma that can distinguish aggressive rhabdoid meningiomas from more benign forms using routine laboratory tests. The new findings could have immediate implications for clinical decision-making, according toRead more
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Nov 15,2016
Creating a Functional Cure for HIV
    The addition of adjuvants to vaccines to stimulate the immune system toward the antigen being injected is a common practice of vaccine delivery. However, trying to awaken the reservoir of dormant viruses in combination with vaccine administration represents a novel approach for human immunodeficiency virus (HIV) research. Yet, that is precisely the path a teamRead more
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Creating a Functional Cure for HIV
Nov 14,2016
Autism Gene Alters Synapse Development
Variants in a gene, DIXDC1, have been found to impair the development of neural connectivity. The variants, which appear to contribute to autism spectrum disorders (ASDs), code for proteins that are equipped with what amounts to an on/off switch. Ordinarily, the DIXDC1 protein can be switched "on” via phosphorylation. Variant forms of the DIXDC1 protein,Read more
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Autism Gene Alters Synapse Development
Nov 14,2016
The Messenger in Huntington's Disease
    Huntington's disease is a neurodegenerative disease that is presently incurable. Scientists around the world are researching its causes and molecular processes in the attempt to find a treatment.     A team of researchers from the Centre for Genomic Regulation (CRG) in Barcelona, in cooperation with investigators from the University of Barcelona (UB) and August Pi iRead more
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Nov 11,2016
Plasmids Shown to Play Key Role in Spread of Antibiotic Resistance
    Researchers at the University of Oxford report that plasmids are one of the key culprits in spreading the major global health threat of antibiotic resistance. Using an Escherichia coli experimental model, the international team of researchers showed that plasmids, which live inside bacteria and are known to be a vehicle for transferring antibiotic resistance genes, can accelerateRead more
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Plasmids Shown to Play Key Role in Spread of Antibiotic Resistance
Nov 11,2016
Domain Swaps Lessen Autoimmunity in TCR Gene Therapy
T cells engineered to express a tumor-specific αβ T cell receptor (TCR) mediate anti-tumor immunity. However, mispairing of the therapeutic αβ chains with endogenous αβ chains reduces therapeutic TCR surface expression and generates self-reactive TCRs. On the surface of the T cell, one T-cell receptor (TCR) type has the makings of an immune party, butRead more
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Domain Swaps Lessen Autoimmunity in TCR Gene Therapy
Nov 10,2016
Mammalian Protein Expression System
Mammalian protein expression systems are the best choice for the production of eukaryotic proteins, especially when correct folding and post-translational modification is required. They produce eukaryotic recombinant proteins in the most natural state, with native tertiary structure, physiochemical characteristics and bioactivities. They have been successfully applied in the biopharmaceutical production of cytokines, monoclonal antibodies, growthRead more
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Mammalian Protein Expression System
Nov 10,2016
Long RNA Research Advance May Lead to New Anticancer Therapies
    Scientists led by a group at the University of Leicester say they have made a breakthrough advance that could pave a new route for the development of anticancer drugs. Ian Eperon, Ph.D., and Cyril Dominguez, Ph.D., from the University of Leicester's Institute of Structural and Chemical Biology, and colleagues published a study ("Identification of G-Quadruplexes in LongRead more
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