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Top 10 Global CDMO Enterprises| The Meaning of IND, NDA and ANDA| Top 10 Global Clinical Research Organizations in 2021
Dec 06,2016
Biomarker Predicts Fatal Leukemia Development in Previously Treated Cancer Patients
    Patients successfully treated for breast, colon and other cancers can go on to develop an often-fatal form of leukemia, sometimes years after completion of treatment, due to a genetic mutation leading to secondary malignancies known as therapy-related myeloid neoplasms (t-MNs).  While risk factors for the development of t-MNs are currently not well understood, a newRead more
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Dec 06,2016
Parkinson Disease Linked to Microbiome
    Only a few decades ago, it would have been largely inconceivable that resident microbes of our digestive tract would play a significant role in neurological diseases. Though roughly 75% of patients with Parkinson's disease (PD) have gastrointestinal (GI) abnormalities, primarily constipation, it had been assumed for many years that this was a side effect ofRead more
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Parkinson Disease Linked to Microbiome
Dec 05,2016
Engineered Flu Virus a Replicative Dud, but Stays Live
    Developing a live vaccine is a tricky balancing act. But it can become more of a sure thing if the vaccine developer puts a thumb on the scales. That's one way to describe the approach taken by Peking University researchers. They decided to tweak the influenza A virus genetically so that it would not onlyRead more
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Dec 05,2016
Survey of Approved Drugs Intended to Shed Light on Potential New Therapies
    Researchers have created a map of all 1578 licensed drugs and their mechanisms of action as a means of identifying "uncharted waters” in the search for future treatments. Their analysis of drugs licensed through the U.S. FDA reveals that 667 separate proteins in the human body have had drugs developed against them—just an estimated 3.5%Read more
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Survey of Approved Drugs Intended to Shed Light on Potential New Therapies
Dec 05,2016
Bioequivalence Study and Data Submission in FDA Abbreviated New Drug Application (ANDA)
Bioequivalence research is a key link in the development and application of generic drugs. As the pioneer and advocate of bioequivalence research, the U.S. Food and Drug Administration (FDA) has in-depth views on it. Starting with the history of equivalence and generic drugs, it introduces the FDA's methodological considerations, experimental design, evaluation standards, and dataRead more
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Dec 02,2016
White Wine May Increase Risk of Skin Cancer
    "A bottle of white, a bottle of red, perhaps a bottle of rose instead,” Billy Joel croons in his famous song "Scenes from an Italian Restaurant.” However, you may want to skip that bottle of white according to a new study from researchers at Brown University's Warren Alpert Medical School. The findings from the newRead more
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White Wine May Increase Risk of Skin Cancer
Dec 02,2016
Modified PEG Drug Delivery Method Evades Immune System Attack
    Duke University biomedical engineers have reconfigured a popular drug-delivery technology to evade immune responses that have halted some clinical trials.         Polyethylene glycol (PEG) is a polymer commonly found in commercial products from toothpaste to cosmetics as well as in pharmaceuticals. PEG is used as a thickener, solvent, softener, and moisture-carrier, but it canRead more
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Dec 02,2016
Scientists Synthesize New Drug Against Chemotherapy-resistant Cancer
The scientists synthesized a new series of compounds called Aminoisothiazole and evaluated their anticancer effects using sea urchin embryos and human cancer cells. One of the molecules was shown to be potent and selectable.
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Scientists Synthesize New Drug Against Chemotherapy-resistant Cancer
Dec 01,2016
A CRISPR Platform That Is More Efficient and Controllable
    A collaborative team of researchers from the Wellcome Trust Sanger Institute and the University of Cambridge has just described their recent work on generating a new CRISPR (clustered regularly interspaced short palindromic repeats) genome-editing platform that is freely available and works as a single-step system within every cell of the body and at every stageRead more
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Dec 01,2016
Novel Technique May Lead to Design of New and Improved Antibiotics
    North Carolina State University scientists say they have discovered a way to make pinpoint changes to an enzyme-driven “assembly line” that will enable researchers to improve or change the properties of existing antibiotics as well as create designer compounds. Their work is the first to efficiently manipulate which building blocks the enzyme selects in theRead more
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