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Top 10 Global CDMO Enterprises| The Meaning of IND, NDA and ANDA| Top 10 Global Clinical Research Organizations in 2021
Feb 09,2017
Eating Grapes Daily Could Prevent Alzheimer's Disease
    Most of us have momentary lapses in memory — we forget a friend's number, a doctor's appointment, or to pay a bill. As we get older, bouts of forgetfulness can sometimes be a symptom of early memory decline, a hallmark of early-stage Alzheimer's disease.     Word has spread through the grapevine of a new study by researchers at UCLA whoRead more
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Feb 08,2017
Molecular Construction Method Allows Synthesis of Valuable Chiral Drugs
    A new technique for constructing chiral drug molecules, whose structural complexity allows them to have mirror-image, "left-handed” and "right-handed” forms, has been developed at The Scripps Research Institute (TSRI). Unlike most previous chirality-inducing reactions, the novel method requires only starting chemicals that are inexpensive and widely available.   Medicilon's drug discovery platform serves the earlyRead more
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Molecular Construction Method Allows Synthesis of Valuable Chiral Drugs
Feb 08,2017
mRNA Vaccine Protects Mice and Monkeys From Zika Virus Infection
    A new Zika vaccine candidate has the potential to protect against the virus with a single dose, according to a research team led by scientists from the Perelman School of Medicine at the University of Pennsylvania. They have developed an investigational vaccine that incorporates messenger RNA (mRNA) and induces a powerfully protective immune response.  AsRead more
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mRNA Vaccine Protects Mice and Monkeys From Zika Virus Infection
Feb 07,2017
Target Identification and Validation in Drug Discovery
    Application Background One of the most important steps in developing a new drug is target identification and validation.  Target-based drug discovery has become the prevailing paradigm used by pharmaceutical and biotechnology companies. This approach is appealing because it holds the promise of identifying more efficacious compounds with fewer undesirable side effects. Good targetRead more
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Target Identification and Validation in Drug Discovery
Feb 07,2017
Mini-Brains Created that Grow Blood Vessels
    Scientists at Brown University have recently made a wondrous variety of mini-brains — 3-D cultures of neural cells that model basic properties of living brains — but a new finding could add to the field's growing excitement in an entirely new "vein”: Brown University's mini-brains now grow blood vessels, too.     The networks of capillaries withinRead more
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Mini-Brains Created that Grow Blood Vessels
Feb 07,2017
Brain Cancer Treatment Puts Skin in the Game
Neural stem cells are self-renewing, multipotent cells that generate the neurons and glia of the nervous system of all animals during embryonic development. Some neural stem cells persist in the adult vertebrate brain and produce neurons throughout life.
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Brain Cancer Treatment Puts Skin in the Game
Feb 06,2017
CRISPR Researchers Create TB-Resistant Cattle
    Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium tuberculosis (MTB).  Tuberculosis generally affects the lungs, but can also affect other parts of the body. Most infections do not have symptoms; in which case it is known as latent tuberculosis.     Tuberculosis (TB) has long been a problem for cattle farmers in developing countries,Read more
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Feb 06,2017
Epigenetic Diversity in Childhood Cancer
    Tumor cells may multiply quickly or slowly, and sow metastasis and dodge the immune system more or less strenuously. All this variability may be ascribed to genetic heterogeneity—but not always. Some cancers have low genetic complexity. For example, childhood cancers tend to harbor less genetic complexity than the cancers that afflict the elderly. And yetRead more
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Epigenetic Diversity in Childhood Cancer
Feb 03,2017
Mapping Large Numbers of Single Cell Genomes Simultaneously
    Single-cell genomics has captured the attention of many molecular biologists and holds the potential to advance research for a variety of different diseases, especially cancer, where tumor heterogeneity is an underlying issue in the development of drug resistance. Now, investigators at Oregon Health and Science University (OHSU) have uncovered a method for quickly and efficientlyRead more
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Mapping Large Numbers of Single Cell Genomes Simultaneously
Feb 03,2017
Viral Capsid Protein Portal May Serve as Drug Target for Attacking Herpesviruses
    To create swarms of new viral particles, a virus hijacks a cell into producing masses of self-assembling “cages,” or capsids, that are then loaded with the genetic blueprint for the next infection. But the picture of how that DNA is loaded into those capsids was blurry, especially for two of the most common types ofRead more
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