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Top 10 Global CDMO Enterprises| The Meaning of IND, NDA and ANDA| Top 10 Global Clinical Research Organizations in 2021
Jun 30,2017
Microneedle Patches for Flu Vaccination Prove Successful in Human Trial
Despite the potentially severe consequences of illness and even death, only about 40 percent of adults in the United States receive flu shots each year; however, researchers believe a new self-administered, painless vaccine skin patch containing microscopic needles could significantly increase the number of people who get vaccinated. An early clinical study at Emory UniversityRead more
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Jun 29,2017
Epigenetic Reprogramming May Boost Immunotherapy
Even when immunotherapy "takes the brakes off” a cancer patient's immune cells, these cells may remain stuck in neutral, or they may act as though they are out of gas, exhausted. Immunotherapy, then, may need to rejuvenate immune cells, specifically T cells, in addition to taking the brakes off via checkpoint blockade. That's the idea.
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Epigenetic Reprogramming May Boost Immunotherapy
Jun 29,2017
Protein Social Networks Mapped Using Novel Next-Gen Sequencing Technique
The social life of proteins is easily as complex and full of drama as the latest Instagram celebrities. However, unlike a rising social network star, understanding how and with whom various proteins interact with inside the cell can ultimately provide useful information about general biology and disease development. Yet, mapping this network of interactions, orRead more
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Jun 28,2017
Fungal Toxins in the Home Can Easily Become Airborne and be Inhaled
Toxins from household fungi can easily become airborne and cause health problems, a new study has found. A team of French investigators has uncovered some new alarming evidence that will likely have major implications on the sick building syndrome (SBS) hypothesis, a medical condition where people in a building suffer from symptoms of illness orRead more
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Fungal Toxins in the Home Can Easily Become Airborne and be Inhaled
Jun 28,2017
New Tool Offers Snapshots of Neuron Activity
Many cognitive processes, such as decision-making, take place within seconds or minutes. Neuroscientists have longed to capture neuron activity during such tasks, but that dream has remained elusive — until now. Scientists at MIT and Stanford say they have developed a technique named FLARE to label neurons when they become active to provide a viewRead more
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Jun 27,2017
Cancer Hijacks Natural Cell Process to Survive
Scientists in the U.K. report that cancer tumors manipulate a natural cell process to promote their survival suggesting that controlling this mechanism could stop progress of the disease. Their study ("A Pan-Cancer Genome-Wide Analysis Reveals Tumour Dependencies by Induction of Nonsense-Mediated Decay”) is published in Nature Communications.
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Cancer Hijacks Natural Cell Process to Survive
Jun 27,2017
Experts Uncover First Molecular Events of Organ Rejection
Researchers at the University of Pittsburgh, School of Medicine and the University of Toronto have uncovered the first molecular steps that lead to immune system activation and eventual rejection of a transplanted organ. The findings may be used someday to create better donor-recipient matches and develop new ways to prevent rejection of transplanted tissues. Curiously,Read more
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Jun 26,2017
Researchers Shed New Light On A Key Player in Brain Development
    Researchers at The University of Texas Medical Branch at Galveston have shed light on how the developing brain ensures that connections between brain cells reach their intended destination but that they are also maintained during life-span.  The team reported its findings ("The glycosylation pathway is required for the secretion of Slit and for the maintenanceRead more
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Jun 26,2017
Best Evidence Yet That Parkinson's Could Be Autoimmune Disease
    Parkinson's begins with abnormal clumping of a protein called synuclein in the brain. Neighbouring dopamine-producing neurons then die, causing tremors and difficulty moving.  Much of the etiology of Parkinson's disease (PD) was thought to be well established, with the noted exception of the hypothesis that has been kicked around for almost a century that PDRead more
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Best Evidence Yet That Parkinson's Could Be Autoimmune Disease
Jun 26,2017
Safety pharmacological test/animal pharmacological test
Safety pharmacology is mainly to observe the adverse effects of the drug on the central nervous system, cardiovascular system and respiratory system when the drug is in the treatment range or above the treatment range. Additional and/or supplementary safety pharmacology studies that may be carried out as needed should also include observations of the urinaryRead more
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Safety pharmacological test/animal pharmacological test