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Top 10 Global CDMO Enterprises| The Meaning of IND, NDA and ANDA| Top 10 Global Clinical Research Organizations in 2021
Jul 10,2017
Colon Cancer-Driven Stem Cells Linked to High-Fat Diet
Poor diet is associated with 80% of colorectal cancer cases, but the exact pathways by which diet leads to cancer are not known.  Scientists in the U.S. have identified a molecular pathway that appears to play a key role in the link between a high-fat diet (HFD) and the development of colorectal cancer. The research,Read more
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Colon Cancer-Driven Stem Cells Linked to High-Fat Diet
Jul 10,2017
Tau Protein Finding May Open Door to Novel Alzheimer’s Therapies
Researchers at the University of California, Santa Barbara (UCSB) say they have advanced our understanding of how the tau protein, associated with Alzheimer's disease, can morph from one physical state to another. In Alzheimer's, tau aggregates to form ropelike inclusions within brain cells that eventually strangle the neurons. Until now, the team points out, howRead more
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Jul 08,2017
hERG test-preclinical cardiac safety evaluation
Cardiac safety evaluation is an important factor that must be investigated before various new drugs enter clinical trials, and it is also one of the most important and difficult links in the early clinical research of innovative drugs. In recent years, some drugs that have been put into clinical use have received extensive attention fromRead more
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hERG test-preclinical cardiac safety evaluation
Jul 05,2017
Mapping Genes Could Improve Cancer Diagnosis
Gene mapping describes the methods used to identify the locus of a gene and the distances between genes.  The essence of all genome mapping is to place a collection of molecular markers onto their respective positions on the genome.  Molecular markers come in all forms. Genes can be viewed as one special type of genetic markers inRead more
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Mapping Genes Could Improve Cancer Diagnosis
Jul 05,2017
Antibiotic Resistance Linked to Household Disinfectant Triclosan
Scientists from the University of Birmingham and Norwich Research Park have found a connection between a major mechanism of antibiotic resistance and resistance to the disinfectant triclosan which is commonly found in many domestic products. Researchers made the unexpected finding that bacteria that mutated to become resistant to quinolone antibiotics also became more resistant toRead more
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Antibiotic Resistance Linked to Household Disinfectant Triclosan
Jul 04,2017
Microglial Cells Shown to Play an Active Part in Alzheimer’s Development
Similar to other neurodegenerative disorders, Alzheimer’s is a disease in which the cognitive abilities of afflicted persons continuously worsen. The reason is the increasing loss of synapses, the contact points of the neurons, in the brain. In the case of Alzheimer’s, certain protein fragments, the β-amyloid peptides, are suspected of causing the death of neurons.Read more
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Jul 04,2017
New Technique Enables Safer Gene-Editing Therapy Using CRISPR
The scientists used CHAMP to provide the first comprehensive survey of DNA recognition by a type I-E CRISPR-Cas (Cascade) complex and Cas3 nuclease. CHAMP, the scientists showed, was able to simultaneously measure the interactions between proteins and ∼107 unique DNA sequences.
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New Technique Enables Safer Gene-Editing Therapy Using CRISPR
Jul 03,2017
Human Protein Engineered to Capture Circulating Tumor Cells
Cancerous tumors are formidable enemies, recruiting blood vessels to aid their voracious growth, damaging nearby tissues, and deploying numerous strategies to evade the body's defense systems.  But even more malicious are the circulating tumor cells (CTCs) that tumors release, which travel stealthily through the bloodstream and take up residence in other parts of the body,Read more
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Human Protein Engineered to Capture Circulating Tumor Cells
Jul 03,2017
Protein Essential for Converting Sound into Brain Signals Identified
Although the basic outlines of human hearing have been known for years, sensory cells in the inner ear turn sound waves into the electrical signals that the brain understands as sound, the molecular details have remained elusive. Nearly 40 million Americans suffer from some level of hearing loss, which includes approximately 74,000 children with profound,Read more
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Protein Essential for Converting Sound into Brain Signals Identified
Jun 30,2017
DNA Methylation Can Help Predict Cancer Prognosis and Survival
Investigators at the University of California San Diego, School of Medicine and at Xijing Hospital and Sun Yat-sen Cancer Center in China say that DNA methylation can provide effective markers for at least four major cancers, not only correctly differentiating malignant tissues from normal, but also providing information on prognosis and survival. "We report thatRead more
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DNA Methylation Can Help Predict Cancer Prognosis and Survival