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Top 10 Global CDMO Enterprises| The Meaning of IND, NDA and ANDA| Top 10 Global Clinical Research Organizations in 2021
Jul 20,2017
Epigenetic Checkpoint Control Could Boost T-Cell Antitumor Activity
Histone deacetylase 11 (HDAC11), an epigenetic enzyme, has been identified as a potential immunotherapeutic target. According to researchers based at George Washington University (GWU), HDAC11 is a negative regulator of T-cell function. Specifically, T cells that express HDAC11 are relatively restrained, whereas T cells that lack HDAC11 are more aggressive, and more effective in destroyingRead more
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Epigenetic Checkpoint Control Could Boost T-Cell Antitumor Activity
Jul 20,2017
Multiethnic Lupus Study Uncovers an Array of New Biomarkers
Lupus is a chronic inflammatory disease that occurs when the body's immune system attacks the tissues and organs. Inflammation caused by lupus can affect many different body systems, including the joints, skin, kidneys, blood cells, brain, heart and lungs. Autoimmune disorders continue to be enigmatic for the scientific community, as researchers are still unsure asRead more
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Multiethnic Lupus Study Uncovers an Array of New Biomarkers
Jul 20,2017
Pharmacokinetics and Pharmacodynamics (PK/PD) Studies
Pharmacokinetic / pharmacodynamics (PK/PD) modeling, an integral component of the drug development process, is a mathematical technique for predicting the effect and efficacy of drug dosing over time. Broadly speaking, pharmacokinetic models describe how the body reacts to a drug in terms of absorption, distribution, metabolism, and excretion. Pharmacodynamic models describe how a drug affectsRead more
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Pharmacokinetics and Pharmacodynamics (PK/PD) Studies
Jul 19,2017
New Study of Brain Circuits Finds Key Links to Symptoms of Depression
Depression affects millions of individuals worldwide, and while current treatments can be useful to control mood and behavioral symptoms, for many, they often paint too wide a stroke, providing counterproductive side effects. Unsuccessful or incomplete treatment of depression stems from our inadequate understanding of the neural pathways that mediate various mood disorders. However now, scientistsRead more
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Jul 19,2017
Gene Synthesis Upgrades Protein Design Massively
Protein designers want to venture boldly into uncharted protein space, but they tend to explore only so far as their computational models and experimental screens allow. Essentially, protein designers hug the shore of what is known about the folding of native proteins. Unfortunately, this approach can take protein designers in the wrong direction. Native proteinsRead more
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Gene Synthesis Upgrades Protein Design Massively
Jul 18,2017
Tiny Cellular Antennae Key to Fat Formation in Muscle
Like it or not, as we age, our muscle cells are slowly exchanged, one by one, for fat cells. This process quickens when we injure a muscle, and an extreme form of this process is also seen in muscle-wasting diseases such as Duchenne muscular dystrophy (DMD). Now, scientists at UC San Francisco have shown thatRead more
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Jul 18,2017
Peptide Half-Life Dramatically Increased Using Novel Approach
Peptides should make ideal drug molecules as they display high target affinity and selectivity, low inherent toxicity, and are easy to synthesize. Unfortunately, peptides also have a short half-life in the body, partly due to enzyme degradation, but primarily because their small size means that they are filtered out of the blood by the kidneys,Read more
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Peptide Half-Life Dramatically Increased Using Novel Approach
Jul 17,2017
Largest Study of Malaria Gene Function Reveals Many Potential Drug Targets
The creation of the aerosol can, the transfer of the Panama Canal construction to the U.S., and the formation of the CDC are all a direct result of malaria's impact on human history, which cannot be overstated. Moreover, this single-cell parasite has been estimated to have caused the death of almost half of the world'sRead more
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Largest Study of Malaria Gene Function Reveals Many Potential Drug Targets
Jul 17,2017
Diabetes Causes Shift in Oral Microbiome That Fosters Periodontitis
The past several years has provided groundbreaking awareness of the role that microbial species on and within our bodies play in maintaining a healthy lifestyle and the onset of disease. Now, a new study led by University of Pennsylvania researchers has found that the oral microbiome is affected by diabetes, causing a shift to increaseRead more
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Diabetes Causes Shift in Oral Microbiome That Fosters Periodontitis
Jul 15,2017
HERG and its evaluation in drug development
Drug safety evaluation plays an extremely important role in drug development. As some non-cardiovascular drugs have been found to induce acquired prolonged QT syndrome (LQTS) and lead to severe arrhythmias (Torsade de Pointes, TDP), they have been withdrawn from the market.It is particularly important to evaluate the safety of drugs to the heart.QT interval ofRead more
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HERG and its evaluation in drug development