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Top 10 Global CDMO Enterprises| The Meaning of IND, NDA and ANDA| Top 10 Global Clinical Research Organizations in 2021
Aug 01,2017
DNA Repair Under the Influence May Raise Risk of Cancer
Genomic infrastructure needs constant upkeep but still falls into disrepair, upkeep or no, if upkeep quality is compromised. In fact, if DNA repairs are poorly executed, they may not only fail to correct the mutations that are due to ordinary wear and tear, they may also introduce additional mutations. These additional mutations, which appear toRead more
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Jul 31,2017
Protein Pair Help Transfer of Chromosomes to the Right Daughter Cell
Cell division is an essential process in humans, animals and plants as dying or injured cells are replenished throughout life. Cells divide at least a billion times in the average person, usually without any problem. However, when cell division goes wrong, it can lead to a range of diseases, such as cancer, and problems withRead more
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Jul 31,2017
Cell-Based Therapies Soften Up Cancer by Targeting Tumor Stiffness
Scientists in the U.S. have created genetically engineered mesenchymal stem cells (MSCs) that can recognize and target "stiff” metastatic tumor tissue and deliver cancer-killing drugs directly to the tumor site. Tests in mouse models of metastatic breast cancer confirmed that the mechanoresponsive cell system (MRCS) can selectively target and destroy cancer cells and shrink tumors,Read more
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Cell-Based Therapies Soften Up Cancer by Targeting Tumor Stiffness
Jul 28,2017
Sunscreen Made of DNA Improves with Longer Wear
Imagine the scene: white sandy beach, turquoise waters, the sound of waves gently rolling into the shoreline. You think to yourself, "This is where I want to spend my day or maybe the even the rest of my days.” As you gently begin to drift away mentally, reality sets in for a moment and youRead more
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Sunscreen Made of DNA Improves with Longer Wear
Jul 28,2017
New Therapies May Come from Discovery How Body Protects Itself from Cancer
Scientists from University of Edinburgh have discovered how damage to the cell's genetic material can trigger inflammation, setting in motion processes to remove damaged cells and keep tissues healthy. The study (“cGAS Surveillance of Micronuclei Links Genome Instability to Innate Immunity”), which appears in Nature, sheds new light on how potentially cancerous cells are flagged, so thatRead more
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Jul 28,2017
Animal Model of Renal Failure
Chronic renal failure (CRF) refers to chronic kidney disease caused by decreased glomerular filtration rate and associated with metabolic disorders and clinical symptoms of the syndrome. The use of animal models can help to understand the occurrence and development of CRF and the prevention and control measures. In recent years, with the deepening of experimentalRead more
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Animal Model of Renal Failure
Jul 27,2017
CRISPR Prevents Beginning Stage of Vision Loss
A research team from the Schepens Eye Research Institute of Massachusetts Eye and Ear has successfully prevented mice from developing angiogenesis of the retina, the sensory tissue at the back of the eye, using gene-editing techniques with CRISPR-Cas9. Angiogenesis causes vision loss and blindness and is a feature of several degenerative eye conditions, including proliferativeRead more
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CRISPR Prevents Beginning Stage of Vision Loss
Jul 27,2017
Knee Joint Signals Bones to Grow
Scientists from the Memorial Sloan Kettering Cancer Center, have revealed a communication system between the knee joint and developing bones in mice, which controls bone growth during early development and after injury. The scientists, who published their findings ("Altered Paracrine Signaling from the Injured Knee Joint Impairs Postnatal Long Bone Growth”) in eLife, concluded thatRead more
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Jul 26,2017
Immune Cells the Missing Ingredient in New Bladder Cancer Treatment
Checkpoint immunotherapy drugs have seen a surge in their adoption as their effectiveness in treating various cancers continues to provide clinical success. Yet, one type of persistent tumor has remained relatively intractable to immunotherapeutic interventions, bladder cancer. However now, a team of researchers led by investigators at the Vancouver Prostate Centre and Vancouver Coastal HealthRead more
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Immune Cells the Missing Ingredient in New Bladder Cancer Treatment
Jul 26,2017
Thousands of Genes Exchanged within Microbial Communities Living on Cheese
The fiercest rat races may be found in microbiomes, communities of microorganisms that are subject to brutal selective forces, environmental fluctuations, toxic chemicals, and nutrient-poor conditions. While it's easy to imagine how rats might cope with desperate circumstances, such as dwindling cheese stores, micoorganisms are rather more mysterious. It is necessary for us to findRead more
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