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Top 10 Global CDMO Enterprises| The Meaning of IND, NDA and ANDA| Top 10 Global Clinical Research Organizations in 2021
Aug 21,2017
Checkpoint Protein Propped Up by Cell-Surface Sidekick
Many cancer cells duck the immune system's T cells by displaying programmed death-ligand 1 (PD-L1), a cell-surface protein that engages programmed cell death protein 1 (PD-1), another cell-surface protein, this one displayed by T cells, and thereby signals T cells to stand down. Although the PD-L1/PD-1 connection is well studied and is the inspiration behindRead more
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Checkpoint Protein Propped Up by Cell-Surface Sidekick
Aug 18,2017
New Machine Learning Program Shows Promise for Early Alzheimer’s Diagnosis
A new machine learning program developed by researchers at Case Western Reserve University appears to outperform other methods for diagnosing Alzheimer's disease before symptoms begin to interfere with every day living, initial testing shows. While there is no cure for Alzheimer's, a number of drugs can delay or prevent symptoms from worsening for up toRead more
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New Machine Learning Program Shows Promise for Early Alzheimer’s Diagnosis
Aug 18,2017
Stroke, Heart Attack Damage Could Be Mitigated via Mimicry of Good Cholesterol
It may be a caricature, but it is recognized by ailing blood vessels, which respond by moving closer to a picture of cardiovascular health. The "it” is an artificial protein called ApoM-Fc that mimics apolipoprotein M (ApoM), a natural protein that is a component of high-density lipoprotein (HDL), or "good cholesterol.” ApoM-Fc performs better thanRead more
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Stroke, Heart Attack Damage Could Be Mitigated via Mimicry of Good Cholesterol
Aug 17,2017
Genetic Risk Factors for Disease Can Be Affected by Environment
It is widely recognized that people respond differently to infections. This can partially be explained by genetics, shows a new study published today in Nature Communications by an international collaboration of researchers from Germany and the United States. A collaborative team of investigators from the University of Bonn, Germany, and the New York Genome CenterRead more
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Aug 17,2017
Precision Medicine for Preventing Suicide
A team of researchers at Indianapolis-based Indiana University School of Medicine say they have created a novel method for diagnosing suicide risk by developing blood tests that work in everyone as well as more personalized blood tests for different subtypes of suicidality and high-risk groups. The researchers also demonstrated how two apps, one based onRead more
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Precision Medicine for Preventing Suicide
Aug 16,2017
Liquid Biopsy Reads RNA Collected by Platelets to Diagnose Cancer
Signs of cancer in the blood are known to include nucleic acids, whether freely floating or tucked inside circulating tumor cells or exosomes. And now it appears that telltale nucleic acids can also be tucked inside platelets. Although platelets lack nuclei and, consequently, RNA of their own, they may gather RNA in their travels, andRead more
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Liquid Biopsy Reads RNA Collected by Platelets to Diagnose Cancer
Aug 16,2017
Circular RNA Linked to Brain Function
Circular RNAs (circRNAs), closed loops of noncoding RNA, drift through the cytoplasm like so many ring buoys floating on the sea. Precisely what the circRNAs are doing there hasn't been clear. Because they are especially abundant in brain cells, circRNAs have been thought to have a role in brain function, possibly via the regulation ofRead more
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Circular RNA Linked to Brain Function
Aug 15,2017
Hair Growth Stimulated Using Stem Cells
A team of researchers from the University of Southern California (USC) in Los Angeles have managed to grow hair starting from stem cells, uncovering key molecular events involved in hair growth and stimulating it in adult mice. The study ("Self-Organization Process in Newborn Skin Organoid Formation Inspires Strategy to Restore Hair Regeneration of Adult Cells”)Read more
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Hair Growth Stimulated Using Stem Cells
Aug 15,2017
Small Molecule Compound Prevents Tooth Decay
In the late 1980's, an advertising campaign for Crest toothpaste pitted a team of toothbrush-toting superheroes against the dreaded "Cavity Creeps,” who sought to destroy the peaceful, dentally entwined city of Toothopolis. In actuality, the evil cavity creeps are bacterial species that are capable of creating sticky biofilms that allow them to be glued toRead more
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Small Molecule Compound Prevents Tooth Decay
Aug 14,2017
A Metabolic Pathway That Feeds Liver Cancer
University of Maryland researchers think they've discovered how a specific gene plays a key role in helping liver cancer cells obtain the nutrition they need to proliferate. Their study ("Silencing of Solute Carrier Family 13 Member 5 Disrupts Energy Homeostasis and Inhibits Proliferation of Human Hepatocarcinoma Cells”) appears in the Journal of Biological Chemistry. Cancer isRead more
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A Metabolic Pathway That Feeds Liver Cancer