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Top 10 Global CDMO Enterprises| The Meaning of IND, NDA and ANDA| Top 10 Global Clinical Research Organizations in 2021
Sep 08,2017
Cancer Invasion Front Gets New Tracking Device
The fog of war is often described by strategists as the level of uncertainty in situational awareness during military operations. Knowing where and when your enemy will attack would, at the very least, offer the opportunity to bolster defenses, if not prevent the incursion altogether. Now, investigators at the University of Michigan have just createdRead more
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Sep 08,2017
Children Exposed to 9/11 Dust Show Signs of Heart Disease Risk
Scientists at NYU Langone Health report that Sixteen years after the collapse of the World Trade Center towers sent a “cloud” of toxic debris across Lower Manhattan, children living nearby who likely breathed in the ash and fumes are showing early signs of risk for future heart disease. The researchers, who analyzed blood tests of 308Read more
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Sep 07,2017
UCLA Biologists Slow Aging, Extend Lifespan of Fruit Flies
UCLA scientists working with middle-aged fruit flies say they were able to improve the insects' health while significantly slowing down their aging process. The team thinks its technique could eventually lead a way to delay the onset of Parkinson's disease, Alzheimer's disease, cancer, stroke, cardiovascular disease, and other age-related diseases in humans. The researchers zeroedRead more
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UCLA Biologists Slow Aging, Extend Lifespan of Fruit Flies
Sep 07,2017
Nuclear Pore Complex under Karyopherin-Centric Control
Although scientists appreciate that the nuclear pore complex (NPC) is more than a complex structure, and that it is, in fact, an intricate machine, they are still trying to work out all the mechanistic details. For example, they are looking for the interlocking gears that drive NPC functions, such as barrier selectivity, the transport ofRead more
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Sep 07,2017
ADME Pharmacokinetics Studies
Absorption, Distribution, Metabolism and Excretion • Absorption ‐ Route of Drug Delivery – Where absorbed? • Distribution ‐ Where does the drug go, where does it need to go and what are the implications?• Metabolism Metabolism ‐ This will occur and could impact several several variables variables. – Could be used to your advantage ‐Read more
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ADME Pharmacokinetics Studies
Sep 06,2017
Bacteria in Throat May Indicate Joint Infection Risk in Kids
Two pediatric centers, one in Canada and the other in Switzerland have shown that the presence of the bacterium Kingella kingae in children's throats was strongly linked to bone and joint infection with the same bacterium.  Their study ("Association between Oropharyngeal Carriage of Kingella kingae and Osteoarticular Infection in Young Children: A Case–Control Study”) appears in CMAJ (Canadian MedicalRead more
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Bacteria in Throat May Indicate Joint Infection Risk in Kids
Sep 06,2017
Virtual Embryo Predicts Real Gene Expression Patterns, Cell by Cell
By the time an embryo starts to show form and structure, every cell in the embryo "knows” its fate, whether it is to become a brain cell, a heart cell, or any other kind of cell. It already has, at this early stage of development, a unique transcriptional identity, one that reflects the cell's positionRead more
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Virtual Embryo Predicts Real Gene Expression Patterns, Cell by Cell
Sep 06,2017
Repeated Dose Toxicity Studies
Repeated dose toxicity studies is the core of non-clinical safety evaluation of drugs, it is acute toxicity, reproductive toxicity and carcinogenicity and other toxicology research, closely linked to the drug from the pharmaceutical research into clinical trials. In the course of drug development, the purpose of the repeated dose toxicity studies is to characterize theRead more
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Repeated Dose Toxicity Studies
Sep 06,2017
High Throughput ADME Study of New Drug Discovery
For the development of innovative drugs, the process consists of three stages and four steps: target discovery, characterization and evaluation (biological target phase); Discovery and optimization of lead compounds (drug discovery phase); ADMET (absorption, distribution, metabolism, excretion and toxicity), PK, PD studies (drug discovery and development phase); clinical trial (drug development stage). High Throughput ADMERead more
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High Throughput ADME Study of New Drug Discovery
Sep 06,2017
Preclinical Pharmacokinetic Experiment
Non-clinical pharmacokinetic studies are based on animal, external and human research methods to reveal the dynamic changes in drugs in vivo, to obtain the basic pharmacokinetic parameters of drugs to elucidate the absorption, distribution, metabolism and excretion of drugs process and characteristics. The main contents of nonclinical pharmacokinetic studies include plasma concentration-time curve determination, absorption,Read more
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Preclinical Pharmacokinetic Experiment