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Top 10 Global CDMO Enterprises| The Meaning of IND, NDA and ANDA| Top 10 Global Clinical Research Organizations in 2021
Sep 21,2017
New Study Shows Promise of Gene Therapy to Treat Alcoholism
Scientists in North and South America have developed a form of gene therapy that could feasibly help to treat alcoholism by causing unpleasant physical side effects in individuals who imbibe. The approach harnesses a short hairpin RNA (shRNA), which is delivered to liver cells using an adeno-associated viral (AAV) vector to prevent expression of aRead more
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Sep 21,2017
Potential Pathway to Treat Flesh-Eating Bacteria
Scientists at the Houston Methodist Research Institute say they have found an important target on which to focus for developing a potential Group A Streptococcus (GAS) vaccine or antibiotic to fight it. GAS infections cause several million cases of strep throat every year, but also can lead to more severe infections, such as flesh-eating disease and acuteRead more
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Potential Pathway to Treat Flesh-Eating Bacteria
Sep 20,2017
CRISPR Reveals the Sugary Secrets of the Cancer Related Notch Protein
The proteins in human cells are extensively decorated with different types of sugars, a phenomenon called glycosylation. These modifications greatly increase the diversity of protein structure and function, affecting how proteins fold, how they behave, and where they go in cells. Scientists at the University of Georgia say they have shown that a rare typeRead more
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Sep 20,2017
Fat-Modifying Enzyme May Be Key to Cancer and Metabolic Diseases
It had already been known that the enzyme known as phosphatidic acid phosphatase (PAP) plays a crucial role in regulating the amount of fat in the human body. Controlling it is therefore of interest in the fight against obesity. Yet now, scientists at Rutgers University-New Brunswick have found that abrogation of the enzyme entirely couldRead more
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Fat-Modifying Enzyme May Be Key to Cancer and Metabolic Diseases
Sep 19,2017
Carbohydrates May Be the Key to a Better Malaria Vaccine
The importance of glycosylation for protein drugs and vaccines has been well established, as companies spend millions of dollars either isolating or creating the appropriate glycosylated form of their desired compound, for increasing efficacy and extend the half-life of the drug. Yet, for the malaria parasite Plasmodium falciparum, researchers have often discounted carbohydrate moieties, sinceRead more
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Sep 19,2017
Love Handles Get Dissolved by New Skin Patch
Researchers have devised a medicated skin patch that can turn energy-storing white fat into energy-burning brown fat locally while raising the body's overall metabolism. The prototype postage-sized microneedle patch could be used to burn off pockets of unwanted fat such as "love handles” and treat metabolic disorders, such as obesity and diabetes, according to researchersRead more
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Love Handles Get Dissolved by New Skin Patch
Sep 18,2017
Sperm Epigenetics May Be Skewed by Exposure to Plastics of Father
Chemicals found in plastics and personal-care products like shaving cream have been known to alter men's hormone levels and diminish semen quality. Now these chemicals, additives called phthalates, have been found to modify sperm epigenetics. Specifically, phthalates have been linked with altered DNA methylation patterns. Although the phthalate-induced epigenetic changes don't disrupt DNA at theRead more
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Sperm Epigenetics May Be Skewed by Exposure to Plastics of Father
Sep 18,2017
Asthma Drug From the Garden Center
The coralberry could offer new hope for asthmatics.  An international team of scientists says they have extracted a new type of active pharmaceutical ingredient from coralberry leaves to combat asthma, a widespread respiratory disease. The leaves contain a substance named FR900359 and it inhibited the contraction of the airways in mice.  The plant itself is notRead more
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Sep 15,2017
Disrupting DNA Loops Could Be Potential Strategy to Reduce Tumor Proliferation
Baylor College of Medicine researchers report that they discover the mechanism by which normal brain cells regulate the expression of the NFIA, or nuclear factor IA, gene, which is important for both normal brain development and brain tumor growth. The team, which believes its discovery will eventually help improve treatments for brain tumors, published itsRead more
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Disrupting DNA Loops Could Be Potential Strategy to Reduce Tumor Proliferation
Sep 15,2017
Doctors Can Now Predict the Severity of Disease Just by Measuring Molecules
An international team of researchers has found a way to diagnose disease and predict patient outcomes simply by measuring unbelievably small changes in interactions between molecules inside the body. The simple new technique could offer vastly superior predictions of disease severity in a huge range of conditions with a genetic component, such as Alzheimer's, autism,Read more
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