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Top 10 Global CDMO Enterprises| The Meaning of IND, NDA and ANDA| Top 10 Global Clinical Research Organizations in 2021
Oct 24,2017
Study Suggests E-Cigarettes Are Just as Harmful as Cigarette Smoking
E-cigarette use around the world is booming, especially amongst young people. In 2016 the US Surgeon General identified a 900 percent increase in e-cigarette use in high school students from 2011 to 2015. While e-cigarette vapor certainly doesn't contain the same kinds of carcinogenic compounds as regular cigarette smoke, there is a growing body ofRead more
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Study Suggests E-Cigarettes Are Just as Harmful as Cigarette Smoking
Oct 24,2017
Novel RNA Switch Dramatically Boosts Expression
Researchers at Northwestern University say they have developed a novel technique that dramatically boosts gene expression. According to Julius Lucks, Ph.D., an associate professor of chemical and biological engineering in the university's McCormick School of Engineering, if scientists could precisely regulate gene expression, they could turn off the genes responsible for illness and disease andRead more
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Novel RNA Switch Dramatically Boosts Expression
Oct 23,2017
Breast Cancer Recycles Toxic Waste to Restock Nitrogen for Growth
Scientists may have hit upon a new therapeutic strategy against breast cancer with the finding that breast tumor cells recycle the ammonia that is generated as a byproduct of normal cell metabolism and use the toxic waste as a source of nitrogen to fuel their growth. The studies, by researchers at Harvard Medical School (HMS) andRead more
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Oct 23,2017
Skin Cancer Starts When Tanning Goes Wrong in Mutated Stem Cells
Melanoma, a cancer of skin pigment cells called melanocytes, will strike an estimated 87,110 people in the U.S. in 2017, according to the Centers for Disease Control and Prevention. A fraction of those melanomas come from pre-existing moles, but the majority of them come from sources unknown — until now. The origin of melanoma, oneRead more
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Skin Cancer Starts When Tanning Goes Wrong in Mutated Stem Cells
Oct 20,2017
Wasabi Pain Pathway in Worms May Lead to New Pain Meds for Humans
Scientists at Northwestern University say they have discovered how scalding heat and tissue injury activate an ancient pain receptor in simple organisms. Their study ("Activation of Planarian TRPA1 by Reactive Oxygen Species Reveals a Conserved Mechanism for Nociception”), published in Nature Neuroscience, may lead to new strategies for analgesic drug design for treating people, noteRead more
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Oct 20,2017
Novel Parkinson's Therapy Suggested by New Research Findings
An international scientific team reports that they have shed light on the molecular mechanism underlying Parkinson's protein LRRK2. The group, which found a direct link between the protein's dimerization and mutations that lead to Parkinson's disease, believes their work could eventually lead to new therapies for this devastating disease. They report the results of theirRead more
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Novel Parkinson's Therapy Suggested by New Research Findings
Oct 20,2017
GLP Toxicology Studies
To assess toxicity, Medicilon offers a wide range of GLP and non-GLP toxicology services. GLP and non-GLP Toxicology studies are required to determine the adverse effects of drug candidates and the effect of dosage on toxicity. Preclinical CRO / Toxicology Studies Include: Late-Stage Discovery Studies Pharmacokinetics Study (PK) Maximum Tolerated Dose Studies (MTD) Dose RangeRead more
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GLP Toxicology Studies
Oct 19,2017
Intermittent Fasting Boosts Fat Burning and Improves Metabolic Function
Studies in mice by a Canadian research team have shown how intermittent fasting (IF) without any calorie restriction results in animals shedding fat and losing body weight, leads to improved glucose homeostasis, and also protects against metabolic dysfunction. The Canadian research team, led by Kyoung-Han Kim, Ph.D., at the Hospital for Sick Children in Toronto,Read more
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Intermittent Fasting Boosts Fat Burning and Improves Metabolic Function
Oct 19,2017
Epigenetics Linked to Resistance for Anti-Cancer Drug
The targeted anti-cancer therapies cetuximab and panitumumab are mainstays of treatment for advanced colorectal cancer, the second leading cause of cancer-related deaths in the United States. However, many patients have tumors with genetic mutations that make them resistant to these anti-epidermal growth factor receptor (EGFR) monoclonal antibodies, or the cancers develop resistance during treatment. ResearchersRead more
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Oct 18,2017
Microbial Drug Resistant Mutations Found via Novel Genome Screen
A scientific team from the Chalmers University of Technology and the University of Gothenburg, Sweden, report the discovery of a number of previously unknown antibiotic-resistant genes. The researchers found the genes by searching large volumes of bacterial DNA collected from humans and various environments from all over the world. Their study ("Identification of 76 NovelRead more
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Microbial Drug Resistant Mutations Found via Novel Genome Screen