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Top 10 Global CDMO Enterprises| The Meaning of IND, NDA and ANDA| Top 10 Global Clinical Research Organizations in 2021
Oct 31,2017
Bacteria Reach Out and Touch Someone
Although bacteria have no sensory organs in the classical sense, they are still masters in perceiving their environment. But now, after a pair of studies, scientists can point to two mechanisms, each involving a different mechanosensing organ. Bacteria, it turns out, may sense surfaces either through their flagella, whip-like appendages used for swimming, or throughRead more
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Oct 30,2017
New Gene-Editing Enzyme Converts A-T to G-C
A new enzyme, called an adenine base editor (ABE), can convert selected A-T base pairs to G-C base pairs, and do so without cleaving DNA. ABE's capabilities may be attributed to its main components: an "evolved” transfer RNA adenosine deamininase (TadA), a Cas9 nickase, and a guide RNA.   ABE can directly repair the typeRead more
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Oct 30,2017
T-Cell Enzyme Uses Deadly Multipronged Attack on Bacteria
In a study that could provide a roadmap for combatting the rising threat of drug-resistant pathogens, researchers have discovered the specific mechanism the body's T cells use to kill bacteria. Scientists have discovered how an enzyme produced by immune system cells carries out a deadly, multipronged attack on invading bacteria. The enzyme, granzyme B, isRead more
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T-Cell Enzyme Uses Deadly Multipronged Attack on Bacteria
Oct 27,2017
Stem Cells Reverse Damage Caused by Incurable Neuromuscular Disease
Being able to reverse the damage caused by neurodegenerative diseases is the ultimate goal of many research endeavors within the neuroscience field. Now, researchers at the University of California San Diego (UCSD) School of Medicine report that a single infusion of wildtype hematopoietic stem and progenitor cells (HSPCs) into a mouse model of Friedreich's ataxiaRead more
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Oct 27,2017
Stress Accompanied by Epigenetic Add-Ons, Many at "Neuropsychiatric" Loci
It has been called the "other" methylated base of DNA. Well studied in bacteria and plants, but relatively mysterious in insects and mammals, this form of epigenetic modification appears to have a role in the brain. It may even be involved in neuropsychiatric disorders.   This other methylated base of DNA is N(6)-methyladenine (6mA). AccordingRead more
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Oct 26,2017
New DNA Replication Model May Open Therapeutic Door
Scientists say their work on a critical step in DNA replication will provide new insights into a fundamental process of life and driver of many different diseases, including cancer. They report the results of their study ("Cryo-EM Structure of Mcm2-7 Double Hexamer on DNA Suggests a Lagging-Strand DNA Extrusion Model”) in PNAS.   "Previous studiesRead more
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New DNA Replication Model May Open Therapeutic Door
Oct 26,2017
Breast Cancer Study Finds 72 New Genetic Risk Variants
An international research consortium has identified 72 new gene variants that predispose to breast cancer, through an analysis of genetic data from more than 275,000 women. Many of the variants lie in regulatory, rather than coding regions, and and additional seven are specific for estrogen receptor-negative (ER-negative) breast cancer.   The OncoArray consortium hopes thatRead more
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Oct 25,2017
If Your Heart Skips a Beat, It Could Be High Thyroid Hormone Levels
When your heart goes pitter-patter, it might not be love, and you may just want to have your doctor check your thyroid hormone levels. New research from a collaborative group of investigators led by scientists at the University Hospital of Bern in Switzerland has found that individuals with higher levels of thyroid hormone (free thyroxine,Read more
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Oct 25,2017
New Protein Aggregation Tool Opens Door to Better Understanding of Neurodegenerative Diseases
A common thread ties seemingly unlinked disorders like Alzheimer's disease and type II diabetes together. This thread is known as protein aggregation and happens when proteins clump together. These complexes are a hallmark of many diseases, but have recently been linked to beneficial functions as well.   Scientists from Boston University (BU), MIT, and the WhiteheadRead more
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New Protein Aggregation Tool Opens Door to Better Understanding of Neurodegenerative Diseases
Oct 25,2017
Bioanalytical Testing Company
Medicilon is the leading Preclinical Contract Research Organization (CRO), providing bioanalytical cro services to the global biopharmaceutical markets. Our protein analytical services could identify a protein by molecular weight, sequence confirm the primary structure of a protein and detect post translational modifications, characterize a protein by aggregation, thermostability, size, charge, and pI, measure a protein'sRead more
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Bioanalytical Testing Company