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Top 10 Global CDMO Enterprises| The Meaning of IND, NDA and ANDA| Top 10 Global Clinical Research Organizations in 2021
Nov 22,2017
A Cancer Cell's Weight Predicts Its Therapeutic Opponent
Doctors have many drugs available to treat multiple myeloma, a type of blood cancer. However, there is no way to predict, by genetic markers or other means, how a patient will respond to a particular drug. This can lead to months of treatment with a drug that isn't working. Scientists in the U.S. have shownRead more
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A Cancer Cell's Weight Predicts Its Therapeutic Opponent
Nov 22,2017
Medicilon successfully passed the US FDA GLP on-site inspection
In September 2017, the FDA inspectors, Dr. Mark Seaton, Dr. Zhou Chen and Ms. Betsy Galliher conducted a comprehensive and detailed examination on the organization and management, personnel, SOP, experimental facilities, archives, experimental implementation, QA system, computerized system of Medicilon.  During the inspection, the FDA inspectors picked a number of research topics to conduct aRead more
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Medicilon successfully passed the US FDA GLP on-site inspection
Nov 21,2017
Evolutionary Backtrack Offers Up Novel Rheumatoid Arthritis Candidate
A peptide found exclusively in Old World monkeys has been shown to completely reverse joint disease in a rat model of rheumatoid arthritis (RA), and could represent a new form of “retroevolutionary'” therapy for RA in humans, according to researchers in the U.S. The peptide, known as rhesus θ-defensin 1 (RTD-1), is the prototype ofRead more
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Nov 21,2017
Antimalarial Drug Repurposed to Treat and Prevent Zika Transmission
Chloroquine's (CQ) success at treating and preventing the spread of malaria is almost immeasurable. The compound was initially developed prior to World War II and initially showed amazing efficacy against the parasitic disease. In combination with vector (mosquito) control efforts to stymie transmission rates, using compounds such as DDT, the World Health Organization (WHO) launched.
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Antimalarial Drug Repurposed to Treat and Prevent Zika Transmission
Nov 20,2017
New Single-Cell Microspectroscopy Methods Could Improve Diagnostics
Noninvasive techniques are typically thought of in reference to the entire patient or large organs, yet what if we were to think about the value of noninvasive techniques at the cellular level. An experimental technique that can noninvasively probe in situ the elastic and the biochemical properties of cells and tissues would be a strategicRead more
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Nov 20,2017
Outside-the-Cell Thinking Simplifies Assembly of Pure Protein Synthesis Machinery
Never mind outside-the-box thinking. Outside-the-cell thinking promises to solve a difficult problem – how to reconstitute cellular reactions outside of biological systems, and to do so in a practical, cost-efficient way. At present, it is difficult to assemble synthetic cell-free systems that can emulate the multistep processes that occur naturally within cells. These cell-free systemsRead more
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Outside-the-Cell Thinking Simplifies Assembly of Pure Protein Synthesis Machinery
Nov 17,2017
Stem Cells in Body Transcriptionally Distinct from Those Extracted for Study
"Not just the FACS, ma'am, not just the FACS.” These words could have come from investigators who have applied a new technique to assess gene expression in stem cells. FACS, or fluorescence-activated cell sorting, is used to remove cells from their native environment and purify them for analysis. Another, newer technique, however, may better reflectRead more
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Nov 17,2017
New Player in Alzheimer’s Disease Pathogenesis Identified
Scientists at the Sanford Burnham Prebys Medical Discovery Institute (SBP) have shown that a protein called membralin is critical for keeping Alzheimer's disease pathology in check. The study ("ER-Associated Degradation Regulates Alzheimer's Amyloid Pathology and Memory Function by Modulating γ-Secretase Activity”), published in Nature Communications, shows that membralin regulates the cell's machinery for producing amyloid-beta (Aβ), theRead more
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New Player in Alzheimer’s Disease Pathogenesis Identified
Nov 16,2017
New Autism Drug Shows Promise in Preclinical Study
There is currently no single drug treatment for autism. Many doctors treat autistic patients with a variety of psychotropic drugs geared at managing their perceived antisocial symptoms, but this is reasonably controversial, especially in children. Research concerning autism spectrum disorder (ASD) has seen its fair share of controversy over the years, but as researchers relentlesslyRead more
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New Autism Drug Shows Promise in Preclinical Study
Nov 16,2017
DNA Replication's Got a Good Beat, and Cancer Can Dance to It
If cancer had ever been interviewed on American Bandstand about a new song, it might have echoed countless teenagers by saying, "It's got a good beat and you can dance to it” – but only if a slow number had just been played. Cancer, it happens, has two left feet when it comes to DNARead more
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