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Top 10 Global CDMO Enterprises| The Meaning of IND, NDA and ANDA| Top 10 Global Clinical Research Organizations in 2021
Dec 05,2017
Esophageal Cancer Linked to Specific Types of Oral Bacteria
At least three kinds of oral bacteria may increase or reduce the risk of developing esophageal cancer, according to New York University (NYU) Langone Health's Perlmutter Cancer Center after an analysis of two national studies that monitored more than 120,000 healthy patients for as long as 10 years.  Their study ("Oral Microbiome Composition Reflects ProspectiveRead more
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Esophageal Cancer Linked to Specific Types of Oral Bacteria
Dec 05,2017
CRISPR Rules When It Obeys the CRISPR Rules
When the gene-editing system known as CRISPR is used, DNA breaks occur fairly reliably, but not DNA repairs – specifically, the repairs that are supposed to insert synthetic donor DNA. But repairs may be more likely to "stick,” say Johns Hopkins scientists, if donor DNA is designed properly.   The scientists suggest that homology-directed repair,Read more
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Dec 04,2017
Protective Alzheimer's Gene Variant Discovered
Sometimes going against the grain produces positive results, and scientific research is no exception. This is the approach that a collaborative team of investigators, led by scientists at Brigham Young University (BYU), took while searching for novel treatments for Alzheimer's disease (AD).   "Instead of identifying genetic variants that are causing disease, we wanted toRead more
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Dec 04,2017
microRNA Gel Helps Damaged Hearts Get to a Better Beat
In mammals, including humans, the cells that contract the heart muscle and enable it to beat do not regenerate after injury. After a heart attack, there is a dramatic loss of these heart muscle cells and those that survive cannot effectively replicate. With fewer of these contractile cells, known as cardiomyocytes, the heart pumps lessRead more
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microRNA Gel Helps Damaged Hearts Get to a Better Beat
Dec 01,2017
Optogenetic Studies Get Major Boost from Advanced Novel Microscope
Scientists from Harvard report the development of a new microscope that greatly improves researchers' ability to study how neurological disorders such as epilepsy and Alzheimer's disease affect neuronal communication. The microscope is optimized to perform studies using optogenetic techniques that use light to control and image neurons genetically modified with light-sensitive proteins. "Our new microscopeRead more
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Optogenetic Studies Get Major Boost from Advanced Novel Microscope
Dec 01,2017
Baby's Microbiome Development Delayed When Antibiotics Given during Labor
As the connection between the gut microbiome and various diseases states continues to grow, researchers have begun to focus their attention on the early stages of human development and how early exposure to certain compounds can perturb the critical balance of species within the microbiota.   An example of this type of research comes fromRead more
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Nov 30,2017
Novel Antibiotic Production Platform Harnesses Synthetic Biology and Chemistry
Researchers from the University of Bristol say they have combined synthetic biology and chemistry to create a modern technology platform to allow the production of novel antibiotics to combat increasing microbial drug resistance. The team is working on derivatives of pleuromutilin, with the core pleuromutilin isolated from the mushroom Clitopilus passeckerianus. Pleuromutilin derivatives are potentRead more
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Nov 30,2017
Fully Functioning Artificial Human Heart Muscle Developed
After a heart attack, scar tissue that can't contract typically replaces dead cardiac muscle, resulting in chronic heart failure – a scourge affecting 12 million people around the world. But regenerating damaged heart tissue has proven challenging, because in order for the heart to beat properly, the muscle must be able to both contract andRead more
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Fully Functioning Artificial Human Heart Muscle Developed
Nov 29,2017
Migraine Sufferers Might Have a Reason to Be Salty
Anyone who suffers from migraine headaches can tell you that the feeling is unlike what most people experience as a headache, and that common drug therapies are often ineffective.   Now, researchers from Heidelberg University in Germany might have stumbled onto an underlying factor that could provide insight into the causes of migraine. The investigatorsRead more
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Nov 29,2017
CRISPR Harnessed to Turn Bacteria into Microscopic Tape Recorders
Scientists have harnessed the bacterial CRISPR/Cas immune system to generate miniature living tape recorders that could feasibly be used to diagnose disease, carry out environmental or microbiological sensing, and record changes in body organs or systems such as the gut. "Such bacteria, swallowed by a patient, might be able to record the changes they experienceRead more
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CRISPR Harnessed to Turn Bacteria into Microscopic Tape Recorders