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Top 10 Global CDMO Enterprises| The Meaning of IND, NDA and ANDA| Top 10 Global Clinical Research Organizations in 2021
Dec 15,2017
Novel Technique Opens Door to Super Resolution of Single Molecules in Cells
Researchers report that they have adapted a technique called DNA-PAINT to confocal microscopes to allow them to investigate molecules deep inside cells. They describe DNA-PAINT as a molecular imaging technology to localize fluorescent dyes.   The team says it is now able to visualize a variety of different molecules, including combinations of different proteins, RNAs, and DNARead more
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Dec 15,2017
Cancer-Causing Mutations Also Boost Tumor Immunoresistance
Mutations in the Ras gene are double trouble. Not only do they drive 25% of human cancers, they also suppress the immune system's anticancer response. Essentially, these mutations turn good cells bad, and they also help bad cells masquerade as good cells by boosting the expression of a protein called PD-L1, or programmed death-ligand 1.Read more
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Dec 15,2017
What are the barriers to the domestic commercialization of CAR T?
Do you know the Prospects of CAR T cell therapy and What are the barriers to the domestic commercialization of CAR T? You can see this in more detail in this article.
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What are the barriers to the domestic commercialization of CAR T?
Dec 14,2017
New Animal Model Developed to Aid Zika Studies
When battling emerging infectious diseases, finding a model that accurately recapitulates the pathogenesis of the infection is critical to developing effective therapeutic interventions. Yet, as most scientists can attest, the things that are the most critical are also most often the most difficult to obtain.
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New Animal Model Developed to Aid Zika Studies
Dec 14,2017
Genetic Differences Could Impact Efficacy and Safety of CRISPR
Studies by researchers in the U.S. and Canada suggest that small differences in the genetic codes of individuals could have a significant impact on the efficacy, side effects and safety of treatments based on CRISPR/Cas9 gene editing. The teams at Harvard Medical School, Boston Children's Hospital, and the Université de Montréal say their findings suggestRead more
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Dec 13,2017
Countering an Epigenetic Factor May Subdue Pancreatic Cancer
A pancreatic cancer cell can alter its identity and become more aggressive – more motile, more invasive, more resistant to chemotherapy, and more imbued with "stemness.” Such a profound shift in identity, reasoned Genentech researchers, might occur at the epigenetic level, where regulatory molecules may control the expression of many different genes. These researchers screenedRead more
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Dec 13,2017
Feeding Overcrowded Bacteria Increases Antibiotic Susceptibility
Antibiotics are commonly ineffective against chronic, hard-to-treat infections caused by bacteria that are present at very high densities. Studies by researchers at the Massachusetts Institute of Technology (MIT) have now suggested why these overcrowded pathogenic organisms become tolerant to treatment and demonstrate how feeding the bacteria with extra nutrients to stimulate respiratory metabolism renders them moreRead more
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Dec 12,2017
CRISPR/Cas9 Edits Epigenome with Therapeutic Efficiency
The kindest cut may be no cut or, in the case of genome editing, no double-strand break (DSB). Although a DSB in DNA is the usual result when the CRISPR/Cas9 genome-editing system is used, modified versions of CRISPR/Cas9 avoid cutting into the genome and instead manipulate the epigenome. Rather than change genes – and riskRead more
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CRISPR/Cas9 Edits Epigenome with Therapeutic Efficiency
Dec 12,2017
Inhibiting Key Nutrient Sensing Pathway May Reverse Age-Related Stem-Cell Loss
Adult stem cells replenish dying cells and regenerate damaged tissues throughout our lifetime. We lose many of those stem cells, along with their regenerative capacity, as we age. Researchers from Stanford University, the Buck Institute, Columbia University, and the USCF School of Medicine, report that TOR, a nutrient sensing pathway which is critical to the aging process,Read more
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Inhibiting Key Nutrient Sensing Pathway May Reverse Age-Related Stem-Cell Loss
Dec 11,2017
Cancer Drug Provides Neuroprotection for Huntington's Disease
Huntington's disease is a devastating, inevitably fatal disease, with no medications that slow or stop disease progression. A drug already used to treat certain forms of cancer may also be an effective therapy for Huntington's disease (HD), according to a new study led by investigators at the University of California, San Diego (UCSD). The sameRead more
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Cancer Drug Provides Neuroprotection for Huntington's Disease