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Top 10 Global CDMO Enterprises| The Meaning of IND, NDA and ANDA| Top 10 Global Clinical Research Organizations in 2021
Jan 08,2018
PCR Primer Analysis
What is a Primer? A primer is a short synthetic oligonucleotide which is used in many molecular techniques from PCR to DNA sequencing. These primers are designed to have a sequence which is the reverse complement of a region of template or target DNA to which we wish the primer to anneal.   PCR ProtocolsRead more
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PCR Primer Analysis
Jan 05,2018
Extra Epigenetic Packaging Keeps Egg Cells Fresh
Keeping egg cells in stasis during childhood is a key part of female fertility. New research sheds light on the role of epigenetics in placing egg cells into stasis through childhood. A team has discovered a distinctive pattern of epigenetic marks that are needed for egg cell stasis. If egg cells don't go into stasisRead more
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Extra Epigenetic Packaging Keeps Egg Cells Fresh
Jan 05,2018
Alcohol Boosts Cancer Risk by Damaging Stem Cell DNA
Alcohol consumption is known to raise the risk of certain cancers, but exactly how alcohol causes cells to stagger toward malignant fates is often unclear. To find ways of keeping cells on the straight and narrow, scientists based at MRC Laboratory of Molecular Biology, Cambridge, used mice to show how alcohol exposure leads to permanentRead more
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Alcohol Boosts Cancer Risk by Damaging Stem Cell DNA
Jan 04,2018
Novel Technique Prevents Ebola from Copying Itself
The incurable Ebola virus has long been feared due to its high mortality rate and danger of infection. Now researchers from the University of Copenhagen and Phillips Universität Marburg have succeeded in inhibiting the virus in cell cultures. The researchers hope to be able to continue doing animal testing and developing an actual drug. "AndRead more
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Jan 04,2018
Cryo-Electron Microscopy Study Opens Door to New Kidney Stone Treatments
Scientists report that they have discovered an ion channel structure that could lead to new approaches to the treatment for kidney stones. The team, which published its study ("Structural Basis of TRPV5 Channel Inhibition by Econazole Revealed by Cryo-EM”) in Nature Structural and Molecular Biology, described atomic-level details of the protein that serves as aRead more
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Jan 03,2018
Advanced Image of A2aAR Protein Could Lead to Better Drug Design Methods
Scientists at The Scripps Research Institute (TSRI) have peered deep into the heart of a key protein used in drug design and discovered dynamic structural features that may lead to new ways to target diseases. The protein, called the A2A adenosine receptor (A2aAR), is a member of the G-protein-coupled receptor (GPCR) family, which are theRead more
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Advanced Image of A2aAR Protein Could Lead to Better Drug Design Methods
Jan 03,2018
Tissue Stresses and Strains Help Scientists Model 3D Shapes
A team of researchers at the University of California, San Francisco (UCSF) has applied relatively simple tissue modeling and cell patterning techniques to generate highly precise 3D shapes, including bowls, coils, and ripples, out of living human and mouse tissues. Zev J. Gartner, Ph.D., and colleagues say the method, which involves patterning mechanically active cells toRead more
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Jan 02,2018
Obesity Leaves Lasting Impression on Blood-Forming Stem Cells
Obesity continues to weigh on the blood-forming stem cell compartment, altering the balance of the cell types produced there, even after the body sheds excess weight. Under the stress of obesity, hematopoietic stem cells (HSCs) begin to overexpress a regulatory gene that tilts blood production toward myeloid cells, and may even promote preleukemic fates. ThisRead more
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Jan 02,2018
New Insights on the Signaling Hub that Drives Cancer Metastasis
A University of Hawaii (UH) Cancer Center researcher has identified how some cancer cells are made to move during metastasis. The research provides a better understanding of how cancer spreads and may create new opportunities for cancer drug development. Joe W. Ramos, Ph.D., deputy director of the UH Cancer Center and collaborators focused on investigatingRead more
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Dec 29,2017
Nanowire Device Developed to Capture Cancer Diagnostic miRNAs from Urine
Cells communicate through a number of mechanisms. Some are well-known: In animals, for example, predatory threats can drive the release of norepinephrine, a hormone that travels through the bloodstream and triggers heart and muscle cells to initiate a “fight-or-flight” response.   Researchers in Japan, Thailand and China have developed a microfluidic device containing embedded nanowiresRead more
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