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Top 10 Global CDMO Enterprises| The Meaning of IND, NDA and ANDA| Top 10 Global Clinical Research Organizations in 2021
Jan 17,2018
Stem Cells Made into Relay Cells for Sense of Touch
For the first time, human sensory interneurons – the cells that communicate the sense of touch in the central nervous system – have been derived from stem cells. In clinical applications, stem cell-derived sensory interneurons could restore feeling in paralyzed patients, potentially complementing stem cell-derived motor neurons, which are being developed to restore coordinated movement.Read more
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Jan 17,2018
TB Vaccine Induces Innate Response via Bone Marrow Stem Cells
Tuberculosis (TB) is an infectious disease usually caused by the bacterium Mycobacterium tuberculosis (MTB).  Tuberculosis generally affects the lungs, but can also affect other parts of the body. Tuberculosis (TB) vaccines, including the well-known Bacillus Calmette–Guérin (BCG) vaccine, have focused on stimulating the adaptive immune system. Unfortunately, attempts to rouse the adaptive immune system againstRead more
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Jan 17,2018
LC-MS/MS Method Development
What Is LC-MS? (LC) Liquid Chromatography: Chromatography is a separations method that relies on differences in partitioning behavior between a flowing mobile phase and a stationary phase to separate the the components in a mixture.A column holds the stationary phase and the mobile phase carries the sample through it.Sample components that partition strongly into theRead more
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LC-MS/MS Method Development
Jan 16,2018
Unhealthy Diet Triggers Epigenetic Changes in Innate Immune System
Exposure to a Western diet high in refined sugars, salt and saturated fat can have a permanent impact on the body's immune system even if the diet is later changed. An international team of researchers has found that the immune system reacts to typically high-calorie, Western-style diets in much the same way that it doesRead more
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Jan 16,2018
Immune System Response to Pediatric Respiratory Infections Molded by Past Exposure
Investigators from the Perelman School of Medicine at the University of Pennsylvania and Children’s Hospital of Philadelphia (CHOP) recently discovered – through analyzing immune cells of children who came to the emergency department with flu symptoms – that a suite of genes expressed by these early-response cells was shaped by factors such as age andRead more
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Jan 15,2018
Engineered Gut Bacteria Provide Enzyme That Helps Green Vegetables Fight Cancer
Colorectal cancer is one of the most common cancers in the world, especially the developed world. Although the 5-year survival rates for earlier stages of this cancer are relatively good, at later stages survival goes down and the risk of cancer recurrence goes up considerably. Scientists in Singapore have developed engineered probiotic gut bacteria thatRead more
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Engineered Gut Bacteria Provide Enzyme That Helps Green Vegetables Fight Cancer
Jan 15,2018
Winding Biological Clock Shortens Cancer's Meal Time
Cancer cells flout the circadian clock's rigid rules, which limit the growth and proliferation of healthy cells. Apparently, cancer cells can jam or disengage the circadian machinery, putting time permanently out of joint. Setting cancer cells right, however, could be an effective therapeutic strategy, particularly since this appears to prevent cancer cells from processing nutrientsRead more
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Jan 15,2018
What is Preclinical Safety Pharmacology Studies importance?
What is Preclinical Safety Pharmacology Studies importance? Identify the adverse pharmacodynamic characteristics of substances that may be related to human safety; Evaluate adverse reactions and/or pathophysiological effects of drugs observed in drug toxicology and/or clinical studies; AndInvestigate the mechanism of observed and/or speculated adverse pharmacodynamic effects.
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What is  Preclinical Safety Pharmacology Studies importance?
Jan 12,2018
Engineered Bacteria Manufacture and Screen Antimicrobial Peptides against Themselves
Biologists at The University of Texas at Austin have developed a method for rapidly screening hundreds of thousands of potential drugs for fighting infections, an innovation that holds promise for combating the growing scourge of antibiotic-resistant bacteria. The method involves engineering bacteria to produce and test molecules that are potentially toxic to themselves. Lead researcherRead more
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Engineered Bacteria Manufacture and Screen Antimicrobial Peptides against Themselves
Jan 12,2018
Novel Method That Images Fat Cells May Lead to New Treatments for Obesity
Researchers from The Rockefeller University’s Laboratory of Molecular Metabolism have created 3D images of fat cells, reportedly the first of their kind. The team says its study, published in Cell Metabolism (“Three-Dimensional Adipose Tissue Imaging Reveals Regional Variation in Beige Fat Biogenesis and PRDM16-Dependent Sympathetic Neurite Density”) reveals the inner workings of fat tissue in mice andRead more
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