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Top 10 Global CDMO Enterprises| The Meaning of IND, NDA and ANDA| Top 10 Global Clinical Research Organizations in 2021
Jan 24,2018
Nonviral Gene Therapy Platform Delivers CRISPR/Cas9 to Tumors
Gene editing is one of the hottest topics in cancer research.  A platform for gene delivery and tumor therapy has been introduced that harnesses the power of the CRISPR/Cas9 gene-editing system. At the same time, the platform avoids some of the drawbacks of the CRISPR/Cas9 system. Specifically, the platform can cope with CRISPR/Cas9's sheer bulk,Read more
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Nonviral Gene Therapy Platform Delivers CRISPR/Cas9 to Tumors
Jan 24,2018
Cancer Stem Cells "Hedge” Their Bets with Noncanonical Signaling
A collaborative team of scientists working as part of the OncoTrack project – an international consortium of scientists funded as part of the European Innovative Medicines Initiative – have recently discovered that cancer stem cells (CSCs) utilize a noncanonical signaling pathway, employing the Hedgehog protein and a positive regulator of WNT. The research team focusedRead more
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Cancer Stem Cells "Hedge” Their Bets with Noncanonical Signaling
Jan 24,2018
DNA Sequencing Services
What is DNA Sequencing? – Determining the precise order of nucleotides in a piece of DNA. – DNA sequence is useful in studying fundamental biological processes and in applied fields such as diagnostic or forensic research. – DNA sequencing methods have been around for 40 years, and since the mid-1970s. DNA Sequencing Goal: Find theRead more
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DNA Sequencing Services
Jan 23,2018
Scientists Develop Single Blood Test That Detects Eight Common Cancers
A research team headed by scientists at Johns Hopkins Kimmel Cancer Center has developed a single blood test that screens for eight common cancer types and helps identify the location of the cancer. The test, called CancerSEEK, identifies eight circulating protein biomarkers and a panel of mutations in 16 cancer genes. When tested on bloodRead more
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Scientists Develop Single Blood Test That Detects Eight Common Cancers
Jan 23,2018
New Nitric Oxide-Converting Enzymes Discovered
Even the smallest molecule can change the course of a cell's future, an apropos modification of J.R.R. Tolkien's writing from the "The Fellowship of the Ring” with respect to a recent discovery by investigators at Case Western Reserve University (CWRU). These researchers have uncovered previously unknown enzymes in the body that convert nitric oxide (NO)Read more
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New Nitric Oxide-Converting Enzymes Discovered
Jan 22,2018
Novel Biomaterials Boost T-Cell Production
T cells play a key role in the body's immune response against pathogens. As a new class of therapeutic approaches, T cells are being harnessed to fight cancer, promising more precise, longer-lasting mitigation than traditional, chemical-based approaches. These "living drugs” are poised to transform medicine, with a growing number of cellular therapies receiving FDA-approval.  Read more
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Jan 22,2018
Learning Gene Passes between Neurons via Retrovirus-Like Mechanism
A neuron's genetic material can literally "go viral.” The genetic material, messenger RNA (mRNA) from the Arc gene, can be passed from neuron to neuron via extracellular vesicles and capsids, rather like retroviral RNA. This finding, which emerged from two recent studies, helps explain why the Arc protein shares features with proteins found in certainRead more
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Jan 19,2018
Magnetically Applied MicroRNAs Could One Day Help Relieve Constipation
Constipation is an underestimated and debilitating medical issue related to the opioid epidemic. As a growing concern, researchers look to new tools to help patients with this side effect of opioid use and aging. Now, investigators from Thomas Jefferson University (TJU) have just released data of a new technique – called magnetofection – that incorporatesRead more
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Jan 19,2018
Cancer Immunotherapy Channeled via Remote Control
A team of researchers has developed an ultrasound-based system that can non-invasively and remotely control genetic processes in live immune T cells so that they recognize and kill cancer cells.   We're a long way from controlling our immune systems as easily as we might change the channels on our televisions, but a new remote-controlRead more
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Jan 18,2018
3D Bioscaffold Mimics Antigen-Presenting Cells for Improved T-Cell Expansion
Researchers have developed a biomaterial scaffold that mimics the actions of antigen-presenting cells (APCs) in stimulating T cell growth and survival. The scaffold allowed the researchers to significantly expand T cell numbers in a dish, compared with existing culture methods, and could bring T cell therapies, such as anti-cancer treatments, closer to clinical reality. LedRead more
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3D Bioscaffold Mimics Antigen-Presenting Cells for Improved T-Cell Expansion