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Top 10 Global CDMO Enterprises| The Meaning of IND, NDA and ANDA| Top 10 Global Clinical Research Organizations in 2021
Jan 30,2018
Botulinum Toxin Jumps to Ubiquitous Bacterial Family
When not used to stiffen the muscles and smooth out the wrinkles on your face, botulinum toxin is regarded as one of the deadlier substances in the world – so much so that it has been (and most likely still is) used as a biological weapon by many nation states. Yet, until now, scientists onlyRead more
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Jan 30,2018
CRISPR's Comrades in Arms Discovered in Microbial Genomes
CRISPR doesn't stand against bacteriophages – viruses that infect bacteria – all by itself. No, this bacterial immune system has fellows deep in the microbial genome's ranks. When these ranks were subjected to systematic inspection by researchers at the Weizmann School of Science, they were found to include 10 previously unknown immune defense systems. SomeRead more
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Jan 29,2018
Mitochondria and Lysosomes Get in Touch, Discuss Regulation
The cell's powerhouse and garbage disposal – two distinct cell structures known as mitochondria and lysosome, respectively – regulate their function by communicating directly with each other within the cell, a new study says. Rather than actually listen in, scientists from Northwestern University employed several imaging techniques: electron microscopy, structured illumination microscopy, and high spatial andRead more
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Mitochondria and Lysosomes Get in Touch, Discuss Regulation
Jan 29,2018
Synthetic Peptides Open Door to New Class of Implantable Medical Devices
Scientists at the University of Sydney's Applied Plasma Physics and Surface Engineering Laboratory say they have developed effective techniques to guide and attach peptides to surfaces. Computer simulations and experiments demonstrated control of both peptide orientation and surface concentration, which can be achieved by applying an electric field like that delivered by a small household-sizedRead more
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Synthetic Peptides Open Door to New Class of Implantable Medical Devices
Jan 29,2018
Immunohistochemistry Techniques
Immunohistochemistry (IHC) is the use of antibodies to detect proteins in tissue samples. The basis of the test is the antibody-antigen interaction that occurs when monoclonal or polyclonal antibodies are applied to tissue sections cut from patient specimens. This reaction can be identified at the microscope by color on slides; a stain that is usuallyRead more
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Jan 26,2018
Universal Flu Vaccine a Nanoparticle That Is All Stalk, No Head
Designs for universal flu vaccines try to emulate the relatively changeless parts of viral proteins, not the highly variable parts that are targeted by seasonal vaccines. The changeless parts, however, tend to be unstable. To develop a vaccine candidate that can present stabilized versions of these relatively changeless structures, scientists based at Georgia State UniversityRead more
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Jan 26,2018
Lack of Microbial Diversity Linked to Polycystic Ovary Syndrome
Women who have polycystic ovary syndrome (PCOS), a common hormone condition that contributes to infertility and metabolic problems, such as diabetes and heart disease, tend to have less diverse gut bacteria than women who do not have the condition, according to researchers at University of California San Diego School of Medicine, in collaboration with colleaguesRead more
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Jan 25,2018
Glycobiology Advance May Lead to Novel Cancer Therapies
Glycobiology is the study of the structure, biosynthesis, and biology of saccharides (sugar chains or glycans) that are widely distributed in nature.  Sugars or saccharides are essential components of all living things and aspects of the various roles they play in biology are researched in various medical, biochemical and biotechnological fields. Scientists at the VanRead more
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Glycobiology Advance May Lead to Novel Cancer Therapies
Jan 25,2018
Personalized Dendritic Cell Vaccines Could Improve Cancer Immunotherapy
Dendritic cell vaccines, a promising cancer immunotherapy approach, usually come from dendritic cells that have been force-fed with tumor antigens. Dendritic cells, however, can also be modified so that they gorge themselves on antigen-carrying exosomes released by tumor cells. Even better, modified dendritic cells aren't finicky. Although ordinary dendritic cells usually consume antigens from lab-grownRead more
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Jan 25,2018
Non Human Primates in Research
Nonhuman primates have been and will continue to be very valuable animal models in biomedical research. For some types of research viable alternatives to the use of nonhuman primates are not available. It is clear, however, that the use of nonhuman primates presents many serious problems for animal health and well-being, animal management and healthRead more
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Non Human Primates in Research