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Top 10 Global CDMO Enterprises| The Meaning of IND, NDA and ANDA| Top 10 Global Clinical Research Organizations in 2021
Feb 06,2018
Common Preservative in Food May Help Schizophrenia Therapy
Toss around the word preservative these days, and you're sure to get a look of detestation from a fair number of people. The much-maligned molecules have come under intense scrutiny in recent years as contributing factors to a host of medical issues – often with scant scientific evidence to support even casual links. Yet now,Read more
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Feb 06,2018
A Little Alcohol Helps the Brain Flush Waste
If you drink moderately – say, a couple of glasses of wine per day – you may want to toast your glymphatic system. It helps clear your brain of metabolites, including the proteins that are associated with Alzheimer's disease and other forms of dementia. According to new research from the University of Rochester, the glymphaticRead more
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A Little Alcohol Helps the Brain Flush Waste
Feb 05,2018
Boosting a Key Protein to Help Bones That Won’t Heal
The occasional bone fracture from a sports injury, motor vehicle accident, or just plain bad luck may seem commonplace in today's world of advanced medical treatments. Yet, there is always the possibility that the break won't heal properly or quickly – even with the aid of pins, plates, or a cast.   Scientists and physiciansRead more
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Boosting a Key Protein to Help Bones That Won’t Heal
Feb 05,2018
Detailed Study of Flu Genome May Help Efforts to Detect Potential Pandemic
The current influenza outbreak – the worst across the United States in nearly a decade – is worrisome but still far less dire than a pandemic flu, which could kill millions.  Pandemic flu occurs when flu strains from different species – birds and humans, or humans and pigs – genetically mix to make a newRead more
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Feb 05,2018
Preclinical Animal Studies
Medicilon provide preclinical animal studies for clients. Animal preclinical studies of drug efficacy are an important resource for designing and performing clinical trials. They provide evidence of a drug's potential clinical utility, inform the design of trials and establish the ethical basis for testing drugs in human. Several recent studies suggest that many preclinical investigationsRead more
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Preclinical Animal Studies
Feb 02,2018
Stealth Virus for Cancer Therapy
The promise of gene therapy to treat cancer has always been limited by the vector used to deliver the rectified genetic payload. While off-targeting has always been a major concern, no less of an issue is the host immune system destroying the therapeutic virus before it has had a chance to complete its mission. Now,Read more
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Feb 02,2018
Gene Duplication Explains Tumor Aggressiveness
Pancreatic cancer is a form of cancer associated with the highest mortality rates in the world. Genetic changes that could explain its aggressiveness and early metastasis are elusive. A team at Technical University of Munich (TUM) has now shown that those characteristics can be explained by specific gene amplifications that occur along evolutionary pathways ofRead more
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Gene Duplication Explains Tumor Aggressiveness
Feb 01,2018
Increasing Sirt4 Activity May Help Treat Age-Related Metabolic Decline and Disorders
Scientists report that fruit flies inhibited from producing the protein Sirt4 are short-lived, while flies modified to make extra Sirt4 are live longer. Flies lacking Sirt4 show increased sensitivity to starvation, decreased fertility and activity, and an inability to use energy stores in their bodies, add the researchers, who say their work suggests that increasing Sirt4Read more
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Increasing Sirt4 Activity May Help Treat Age-Related Metabolic Decline and Disorders
Jan 31,2018
Immune Disorder Trigger Identified
Scientists in the U.S. have identified a promising target for treating immune system-related disorders that are associated with mutations in a gene known as GTPase of immunity-associated protein 5 (Gimap5). The researchers, led by the team of Kasper Hoebe, Ph.D., at the Cincinnati Children's Hospital Research Foundation, used inhibitors of glycogen kinase 3β (GSK3β) –Read more
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Immune Disorder Trigger Identified
Jan 31,2018
Drug Shows Promise for Calming Overeager Stem Cells
Like overeager runners at the starting line, stem cells sometimes jump the gun, disqualifying themselves and losing the chance to enter the winner's circle. For would-be therapeutic stem cells, the winner's circle is a transplantation site. It can be reached only if stem cells pace themselves and avoid differentiating too soon.   To keep stemRead more
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