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Top 10 Global CDMO Enterprises| The Meaning of IND, NDA and ANDA| Top 10 Global Clinical Research Organizations in 2021
Feb 12,2018
Altruistic Immunity Could Be Key to Stopping Spread of Malaria
"Throwing a wrench into the works” is a common colloquial phrase used to describe how a complex plan can be disrupted by one simple action. This is most often the approach that scientists use when developing treatment strategies for debilitating disorders and could be the key to preventing the transmission of parasitic infections like malaria.Read more
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Altruistic Immunity Could Be Key to Stopping Spread of Malaria
Feb 12,2018
Toxicity Testing Methods
Knowledge of toxicity is primarily obtained in three ways: By the study and observation of people during normal use of a substance or from accidental exposures By experimental studies using animals By studies using cells (human, animal, plant) Workplace modern laboratory for molecular biology test on blue background Most chemicals are now subject to stringentRead more
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Toxicity Testing Methods
Feb 12,2018
What is Toxicokinetics?
Toxicokinetics is essentially the study of "how a substance gets into the body and what happens to it in the body”. Four processes are involved in toxicokinetics. Four processes in toxicokinetics The study of the kinetics (movement) of chemicals was originally conducted with pharmaceuticals and thus the term pharmacokinetics became commonly used. In addition, toxicologyRead more
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What is Toxicokinetics?
Feb 12,2018
Toxicology Testing Labs
Animal tests for toxicity are conducted prior to human clinical investigations as part of the non-clinical laboratory tests of pharmaceuticals. For pesticides and industrial chemicals, human testing is rarely conducted. Animal test results often represent the only means by which toxicity in humans can be effectively predicted. With Animal Tests: Chemical exposure can be preciselyRead more
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Toxicology Testing Labs
Feb 09,2018
Triple-Negative Breast Cancer Cell Growth May Be Driven by Tumor "Suppressor”
A member of a protein family that has previously been thought to play a tumor-suppressive role in breast cancer may in fact be key to the maintenance of self-renewing cancer stem cells (CSCs) that drive one of the most aggressive form of the disease. Studies by a Cleveland Clinic team, headed by Justin Lathia, Ph.D.,Read more
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Triple-Negative Breast Cancer Cell Growth May Be Driven by Tumor "Suppressor”
Feb 09,2018
Model Wound System Created that Self Heals
Biomedical engineers have developed a miniature self-sealing model system for studying bleeding and the clotting of wounds. They view the device as a drug discovery platform and potential diagnostic tool that is described in Nature Communications ("A Microengineered Vascularized Bleeding Model That Integrates the Principal Components of Hemostasis”). "…here we develop a comprehensive in vitroRead more
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Model Wound System Created that Self Heals
Feb 08,2018
Leaky BBB and Toxic Fibrinogen Linked with Early Stages of Dementia
Scientists in the U.S. have identified mechanisms that could underpin the earliest stages of about 50% of all dementias, including Alzheimer's disease (AD), well before the telltale accumulation of protein clumps and tangles in the brain. Researchers at the Keck School of Medicine, University of Southern California (USC) used a combination of mouse models, magneticRead more
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Feb 08,2018
CRISPR Technique Could Correct Majority of Thousands of DMD Mutations
Scientists have developed a CRISPR gene-editing technique that can potentially correct a majority of the 3,000 mutations that cause Duchenne muscular dystrophy (DMD) by making a single cut at strategic points along the patient's DNA, according to a study from University of Texas (UT) Southwestern Medical Center. In proof-of-concept studies, Eric Olson, Ph.D., and colleaguesRead more
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CRISPR Technique Could Correct Majority of Thousands of DMD Mutations
Feb 07,2018
Study Sheds Light on How Darkness Produces Dimwits
The structure of the brain, and even the ability to learn and remember knowledge, may be hampered by spending too much time in dim light, researchers at Michigan State University have concluded, in a just-published, first-of-its-kind study likely to reinforce why bright is a synonym for smart.   The researchers exposed Nile grass rats toRead more
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Feb 07,2018
Grape-Derived Compounds May Help to Prevent Depression
Natural compounds derived from grapes may help treat depression by targeting newly discovered underlying mechanisms of the disease.  Scientists have identified two grape-derived compounds that can effectively help to treat and protect against stress-induced depression in mice, and which could represent promising new candidates for treating depression in humans. The compounds, dihydrocaffeic acid (DHCA) andRead more
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