Medicilon Human Disease Animal Model

2020-07-01

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Medicilon provides various effective animal models according to customer needs to test the effectiveness of drugs. Experimental animals include non-human primates, dogs, mice, rats, rabbits, and guinea pigs. At present, we have established a number of effective animal models, and have passed multiple verifications and long-term practical tests. At the same time, our employees’ rich experience and strong theoretical foundation can flexibly develop and build various customized models according to customer’s customization requirements to meet customer needs.

Tumor disease model

Medicilon provides various effective animal models according to customer needs to test the effectiveness of drugs. Experimental animals include non-human primates, dogs, mice, rats, rabbits, guinea pigs, and nude mice. At present, we have established a number of effective animal tumor models, and have passed multiple verifications and long-term practical tests. At the same time, our employees’ rich experience and strong theoretical foundation can flexibly develop and build various customized tumor disease models according to customer’s customization requirements to meet customer needs. see more

Type of cancer (tumor model)	Cell line
Head and neck tumor model	KB, FaDu
Animal model of nasopharyngeal carcinoma Stem cell animal model	S18, S26
Lung cancer animal models	DMS114, NCI-H69, NCl-H146, NCl-H209, NCI-H446, NCI-H526, NCI-H1688, 95-D, A549, Calu-1, Calu-3, Calu-6, HCC827, NCI -H226, NCI-H292, NCI-H358, NCI-H441, NCI-H460, NCI-H520, NCI-H522, NCI-H1299, NCI-H1437, NCI-H1650, NCI-H1975, NCI-H1993, NCI-H2009 , NCI-H2122, NCI-H2126, NCI-H2228, PC-10, QG-56
Breast cancer animal models	SUM159, MDA-MB-231, MDA-MB-468, Bcap-37, 2LMP, ZR-75-1, ZR-75-30
Animal model of gastric cancer	MKN-45, NCI-N87, BGC-823, HGC-27, MKN-28, NUGC-3, SCH, SGC-7901, SNU-5, SNU-16, MGC-803
Animal model of pancreatic cancer	AsPC-1, BxPC-3, Capan-1, Capan-2, CFPAC-1, HPAF-II, MIAPaCa-2, PANC-1
Kidney cancer animal model	ACHN, OS-RC-2, 786-O
Liver cancer	Bel-7402, Hep-3B, Huh-7, PLC/PRF/5, QGY-7703, SK-HEP-1, SMMC-7721, HepG-2
Glioblastoma	U87-MG
Colon and cecum cancers	COLO 201, COLO 205, COLO 320 DM, CW-2, DLD-1, HCT-8, HCT-15, HCT-116, HCT116 P53 K0(-/-), HT-29, LoVo, LS1034 , LS174T, LS411N, NCI-H716, RKO, SW48, SW620 Prostate cancer 22Rv1, CL-1, DU145, LNCap Clone FGC, PC-3
Bladder	HT-1197, HT-1376, RT4, SCaBER, SW780, T24
Ovarian cancer	ES-2, HO-8910PM, PA-1, SK-OV-3, OVCAR-3
Endometrium / Hysterocarcinoma	AN3 CA, HEC-1-A, ME-180, MFE-280
Skin cancer cell	A431
Melanoma	A375, B16, A2058, C32, HMCB, SK-MEL-30, MDA-MB-435s
Osteosarcoma cells	MG-63, SJSA-1
Sarcoma	S-180
Muscles, stripes	SJCRH30
Myeloma	KMS-11, KMS-26, RPMI-8226
Leukemia/lymphoma	U937, THP-1, MV-4-11, HEL, TF-1a, ML-2, HL-60, L1210, K562, KARPAS-299, Daudi, Raji, Ramos, ARH-77, KMS- 12-BM, KG-1

Digestive system disease model

Medicilon provides various effective animal models (renal failure model, anemia animal model, gastric acid secretion animal model, gastric ulcer model, etc.) according to customer needs to test the effectiveness of drugs. Conventional diseases of the digestive system include: gastric acid secretion, gastric ulcer, renal failure, etc. Animal experiments are carried out in rats.

disease	The Digestive system disease model	The Test animal
Renal failure	The Nephrectomy (5/6)	The Rat
anemia	The Renal failure induction	The Rat
Gastric acid secretion	The Histamine gastric acid secretion model	The Rat
	The Pylorus ligation model of gastric acid secretion	The Rat
	The Ethanol gastric ulcer model	The Rat
Gastric ulcer	Aspirin gastric ulcer model	The Rat

Endocrine and Metabolic Disease Model

Medicilon provides a variety of effective endocrine disease models and animal models of metabolic diseases according to customer needs to test the effectiveness of drugs. Conventional endocrine diseases and metabolic diseases include: diabetes, obesity, dyslipidemia, etc. Animal experiments are conducted with large mice and hamsters.

Disease	Endocrine and Metabolic Disease Model	Animal
Diabetes	Streptozotocin Diabetes	Mice
	Spontaneously diabetic	db/db, ob/ob mice
	Obese mice induced by high-fat diet	DIO mice
Obesity	Hereditary	db/db, ob/ob mice
	Obese mice induced by high-fat diet	DIO mice
	Dyslipidemia High fat/cholesterol	Hamster

Inflammation and immune disease models

Medicilon provides various effective inflammatory disease models and animal models of immune diseases according to customer needs to test the effectiveness of drugs. Conventional inflammation and immune diseases include: acute inflammation, arthritis, experimental allergic encephalomyelitis, etc. Animal experiments are conducted with large mice. see more

Nervous system disease model
Medicilon provides a variety of effective animal models (depression animal models, Parkinson’s disease animal models, psychotic animal models, etc.) according to customer needs to test the effectiveness of drugs. Routine neurological diseases include: psychosis, Parkinson’s disease, depression, pain (central), etc. Animal experiments are conducted with large mice and guinea pigs. see more