As an important part of drug research and development, chemically synthesized drugs are still the subject of new drug research and development for major pharmaceutical companies in the world today. The production of chemical drugs is inseparable from three stages: raw material pretreatment, chemical reaction and product refinement. Chemical drugs can be inorganic minerals or synthetic organic compounds, effective monomers extracted from natural drugs, or antibiotics obtained by fermentation. In the future, the development of chemically synthesized drugs presents the following development trends:
Chinese herbal medicine has been used for thousands of years, and very valuable experience has been obtained in the treatment of various diseases including tumors. Abundant Chinese herbal medicine resources also provide an important material basis for the search for new anti-cancer drugs. Natural products are the largest and best source of medicines. Not only are the medicines used in various traditional medicines in the world belong to natural sources, even if they are used in modern medicine. The number of natural-derived compounds in the chemical drugs in China also exceeds 30%, and more drugs are produced by structural modification and transformation of natural products as lead compounds. The diversity of the structure and biological activity of natural products can not only directly provide new drugs or drug-leading compounds, but also provide inspiration for chemical synthesis and structural modification. Discovering novel lead compounds with antiviral and antitumor activity from medicinal plants is one of the important directions for the development of antiviral and antitumor drugs.
Medicilon can undertake the synthesis of special reagents, intermediates and molecular fragments, preparation of standard products, synthesis design and preparation of impurities or metabolites, synthesis of stable isotope internal standards and synthesis of tritiated compounds.
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Medicilon can provide customers with high-efficiency and maximum production capacity preparation process optimization services, saving customers time and cost, and producing reliable and cost-effective intermediates and API products for customers. The main research and development projects include: chemical drug synthesis process Optimization, preparation process optimization, etc.
Nowadays, antimicrobial drug resistance is everywhere, and it may affect people of any age in any country. Many of the medical breakthroughs made in the last century may be lost due to the spread of antimicrobial resistance, and previously curable infectious diseases may become untreatable and spread throughout the world. Antimicrobial drug resistance is a global problem. In the past few years, the use and misuse of antimicrobial drugs has increased the number and types of drug-resistant microorganisms. As a result, multiple infectious diseases may become uncontrollable again. With the increase in global trade and travel, drug-resistant microorganisms may rapidly spread to every corner of the world.
The application of combinatorial chemistry technology to obtain new compound molecules is a development of bionics. It assembles some basic small molecules into different combinations to build a chemical molecule library with a large number of compounds, and then combines high-throughput screening to find some active lead compounds.
Most of the drugs are organic compounds, and the current synthetic drugs are also prepared by organic chemistry synthetic methods. At present, chemically synthesized drugs are still the most effective, most commonly used, largest and most important therapeutic drugs. Nowadays, the subject of new drug research by major pharmaceutical companies in the world is still chemically synthesized drugs
Entering the 21st century, a batch of inventions with advanced computer equipment, continuous improvement of separation and analysis methods, especially the further miniaturization of analysis methods, will further improve the quality of chemically synthesized drugs and further accelerate the development speed.
Pharmacology is further branched into molecular pharmacology, biochemical pharmacology, immunopharmacology, receptor pharmacology, etc. In the future, chemical synthesis of drugs will closely promote the development of pharmacology, and the progress of pharmacology will promote the development of chemical synthesis of drugs. A more specific direction will make it not only have better medicinal effects, but also reduce toxic and side effects.
In the 21st century, the three-dimensional structure of enzymes, receptors, and proteins will be elucidated one by one, which lays a solid foundation for the development of new chemically synthesized drugs by using these “biological targets” that have been clarified for rational drug design. .
The rapid progress of molecular biology technology and the research achievements of human genomics will have a significant impact on clinical medication. It will not only help discover a new type of trace endogenous substances, such as active proteins, cytokines and other drugs, but also The research of chemical synthetic drugs, especially the provision of new targets, has laid an important foundation. Chemical drugs are a class of special chemicals with a clear structure that can prevent, treat, or diagnose diseases, or regulate human functions, improve body quality, and maintain physical health. They are closely related to humans and are part of the applications in human daily life. As a means of synthesizing chemical drugs, chemically synthesized drugs will become more and more important in the future.
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