Animal Disease Model

1. What is Animal Disease Models?

    Animal models of human diseases refer to animal experimental objects and related experimental materials established in the process of biomedical research that simulate human diseases.

2. The Significance of Animal Disease Models

(1) Alternative

•Clinically research on trauma, poisoning, tumor, etc. cannot be repeated in human body, and many scientific data must not be collected by causing human to suffer;

•As a substitute for humans, animals can be repeatedly observed under specific experimental conditions designed by humans, and animals can be sacrificed to obtain required animal tissues and organs.

• Risks, hazards and ethical issues arising from human experiments are avoided.

(2) Disease materials with low incidence, long incubation period and long course of disease can be provided

•Clinically hereditary, immune, metabolic and endocrine, blood and other diseases have a low incidence, and can replicate relevant animal models for research.

•Clinically tumors, chronic bronchitis, atherosclerosis and other diseases have a long incubation period and a long course of disease, which can reach decades.

• Diseases with long incubation periods, long duration and low morbidity

(3) Controllable

•Diseases are complex and are related to the patient's age, gender, constitution, heredity, and environment.

• When replicating animal models, animals of the same strain, sex, age, and body weight can be selected, and the microbial control (infection of pathogens) and experimental environment standards are also completely consistent;

• Therefore, other influencing factors can be excluded to make the experimental results more accurate and in-depth. Methodological comparability can be increased.

(4) Convenience

Animal models, as "replicas" of human diseases, can be based on experimental needs: • Samples are easily available • Analytical experiments are simplified.

(5) Conducive to a more comprehensive understanding of the nature of the disease

3. Classification of Animal Models of Human Diseases

•Classified by cause:

–Spontaneous animal model

–Induced animal model

– Genetically engineered animal model

• System-wide classification

– Basic pathological process of disease: inflammation, tumor, shock

– Animal models of diseases of various systems: cardiovascular, respiratory, digestive, occupational diseases

• Sort by model type

– Whole animals, isolated organs and tissues, cell lines, etc.

4. Factors Affecting the Quality of Disease Models

1. The effect of model-causing factors on the replication of animal models;

2. The influence of animal factors on the replication of animal models (standardized experimental animals for wild animals and domestic animals);

3. The influence of experimental technical factors on the replication of animal models;

4. The influence of environmental factors and nutritional factors on replicating animal models.

5. Design Principles of Animal Disease Models

•(1) Similarity and comparability

•(2) Repeatability

•(3) Reliability

•(4) Applicability and controllability

•(5) Ease of operation and economy

6. Precautions for Disease Animal Models

• No animal model can completely replicate human disease, and the correctness of model experiment conclusions is only relative, and must ultimately be verified in humans.

• Keep the model animal as minimal as possible and with the least disturbance;

• The advanced degree of animal evolution does not mean that all organs and functions are close to the degree of human beings; inbred animals cannot be used blindly;

• Search literature and consult whether animals and conditions required for animal experiments are feasible, understand the experience accumulated by predecessors, and avoid waste of human and material resources caused by low-level repetition or blind movement without scientific basis.

The following is the animal model of Medicilon human diseases compiled by the editor for you. For the latest model information, please contact us.

Tumor disease model

      Medicilon provides a variety of effective animal models to test the effectiveness of drugs according to customer needs. Experimental animals include non-human primates, dogs, mice, rats, rabbits, guinea pigs, nude mice and other species. At present, we have established a number of effective animal tumor models, which have been verified by various parties and tested in long-term practice. At the same time, our staff's rich experience and solid theoretical foundation can flexibly develop and establish various customized tumor disease models according to customer's customized requirements to meet customer needs. See more.

Digestive System Disease Model     

Medicilon provides various effective animal models (renal failure model, anemia animal model, gastric acid secretion animal model, gastric ulcer model, etc.) according to the needs of customers to test the effectiveness of drugs. Conventional digestive system diseases include: gastric acid secretion, gastric ulcer, renal failure, etc., animal experiments are carried out through rats. See more.

Endocrine and Metabolic Disease Models

Medicilon provides a variety of effective endocrine disease models and metabolic disease animal models to test the effectiveness of drugs according to customer needs. Conventional endocrine diseases and metabolic diseases include: diabetes, obesity, dyslipidemia, etc. Animal experiments are carried out through rats, hamsters, etc. See more.

Inflammatory and Immune Disease Models

Medicilon provides a variety of effective inflammatory disease models and immune disease animal models according to customer needs to test the effectiveness of drugs. Conventional inflammatory and immune diseases include: acute inflammation, arthritis, experimental allergic encephalomyelitis, etc. Animal experiments are carried out in rats and mice. See more.

Nervous System Disease Models

Medicilon provides various effective animal models (depression animal model, Parkinson's disease animal model, psychotic animal model, etc.) according to the needs of customers to test the effectiveness of drugs. Conventional neurological diseases include: mental illness, Parkinson's disease, depression, pain (central), etc., through animal experiments such as rats and guinea pigs. See more.

Contact us

Email: marketing@medicilon.com