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The application of animal models provides a vital tool for drug research. Pharmacodynamic modeling is based on a quantitative integration of pharmacokinetics, pharmacological systems, and physiological processes to understand the intensity and time course of a drugs effect on the body. Medicilon has established drug efficacy evaluation models covering most major human diseases, providing technical support for drug efficacy screening and clinical translational research.Animal efficacy models are important for new drug candidate screening in preclinical drug discovery research.
Animal models play an essential role in the preclinical drug evaluation system. The establishment of animal models provides a powerful tool for studying the mechanism of disease occurrence and development, screening, and evaluating the efficacy of drugs.
Rodents are the most widely used models in biomedical research and preclinical drug evaluation and have proven invaluable for developing new drugs for many human conditions.
IO Pharmacodynamic Model Evaluation Platform
Preclinical models are widely used to evaluate anticancer agents in the drug discovery/development phase and assess combination therapies. Animal tumor models have provided opportunities to investigate the underlying molecular basis of cancer, which spans tumor initiation, growth, metastasis, and mechanisms of therapeutic evasion.
Pharmacodynamic Evaluation Model Platform for Inflammatory and Immune Diseases
Translational immunology assays and inflammation models that accurately reflect the human immune system are powerful tools to advance your immunology research. Medicilon has developed numerous pharmacology, efficacy, and mechanical actions immunology models to support your drug development.
Rodent Cerebrovascular Disease Drug Efficacy Evaluation System
In hypertension, the utility of animal models for improving the understanding of the pathogenesis, prevention, and treatment of hypertension and its comorbidities depends on their validity for representing human forms of hypertension, including responses to therapy.
Medicilon Drug Resistant Tumor Models
Drug resistance of tumors refers to the phenomenon where tumor cells in the patient’s body develop higher tolerability to the original therapy post a period of treatment, leading to a compromised therapeutic benefit and disease progression.
Medicilon Preclinical Nociceptive Pain Models
Currently, Medicilon possess different types of pain including acute pain, inflammatory pain, and neuropathic pain. We have developed many common methods used for inducing each of the pain phenotypes related to clinical pain syndromes, as well as the main behavioral tests for assessing pain in each model.
Medicilon Ophthalmic Animal Models
Dry eyes affect a significant number of people, the cause of dry eye is multifactorial. Medicilon has established ocular diseases models, including the Conjunctival tissue proliferation and NV, Diabetic retinopathy (DR), Choroidal neovascularization (CNV) and subretinal fibrosis, Corneal neovascularization (Corneal NV), Retinal neovascularization, Acute ocular inflammation, and dry eye models.
- Medicilon continues to expand the animal models it offers to optimize preclinical drug efficacy tests, thereby promoting the development of treatments for various diseases.
