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ABOUT
| Serial Number | Instrument/Type | Instrument Model |
|---|---|---|
| 1 | Nuclear Magnetic Resonance NMR | Bruker 400 MHz |
| 2 | LC-MS | Shimadzu LC-MS 2020 |
| Waters UPLC-Qda | ||
| Agilent 6120 | ||
| 3 | GC-MS | Agilent 7890B |
| Shimadzu GC-MS 2020 | ||
| 4 | High Performance Liquid Chromatography (HPLC) | Agilent 1200； |
| Shimadzu 20AD | ||
| 5 | Chiral Sample Analysis (UPCC/HPLC) | Waters UPCC |
| Shimadzu 20AD | ||
| 6 | Residual Solvent Analysis (GC-HS) | Agilent GC-HS 7890B |
| Shimadzu GC-2010 plus | ||
| 7 | Ion Content Analysis (IC) | Thermo IC 5500 |
| 8 | Metal Element Analysis (ICP-MS) | PE NexION 1000 |
| 9 | UV Spectrum (UV) | PE LAMBDA 365 |
| 10 | Infrared Spectrum (IR) | PE Spectrum Two |
| 11 | Optical Rotation Test (OR) | Anto Paar MCP5300 |
| 12 | Differential Thermal Analysis (DSC) | METTLER DSC 3 |
| 13 | Thermogravimetric Analysis (TGA) | METTLER TGA 2 |
| 14 | Moisture Test (KF) | METTLER V30S |
| METTLER C30SX | ||
| 15 | Ignition Residue Test (ROI) | Muffle |
| 16 | Loss On Drying Test (LOD) | Oven |
| METTLER HX 204 | ||
| 17 | Melting Point Test (MP) | METTLER MP 70 |
| 18 | Solution Clarity Analysis | Clarifier |
| 19 | Solubility Test | Visual Method |
| 20 | Microbial limit Test | Pharmacopoeia Standard Test |
- （1）Medicilon can undertake various business-analysis projects:
Serial Number project Use the instrument 1 diQ-NMR NMR 2 Structural Confirmation NMR 3 Impurity Standardization (declaration) HPLC, GC-HS, Moisture Meter, ROI 4 API Standardization (declaration) HPLC, GC-HS, Moisture Analyzer, ROI, Titrator 5 Compound main peak preparation Pre-HPLC 6 Impurity preparation Pre-HPLC 7 Chiral method screening and splitting SFC 8 Stability test Stability box, HPLC, GC-HS and physical and chemical instruments 9 GC-HS methodology development and validation GC-HS 10 GC-MS methodology development and validation GC-MS 11 HPLC methodology development and validation HPLC 12 ICP-MS method development and verification ICP-MS 13 IC method development and verification IC 14 LC-MS-MS method development and verification LC-MS-MS 15 Microbial limit method development and verification Microbiology laboratory 16 Safety Assessment Laboratory DSC、RC1 17 Safety Assessment Laboratory ARC
Main large instruments:
Nuclear Magnetic Resonance Spectrometer NMR
model: Bruker Avance Ⅲ HD 400 MHzMain functions: Suitable for molecular structure analysis, content determination, known structure confirmation and unknown structure prediction and reaction mechanism research in chemistry, medicine and the chemical industry. It can test the NMR Spectrum of various cores such as H, C, F, P, B and so on; equipped with PABBO SP probe, it can be used for 1H, 13C, DEPT, NOESY, COSY, HMBC, HSQC and other 1D and 2D homonuclear and heteronuclear Related experiments and variable temperature experiments.
Inductively coupled plasma mass spectrometer ICP-MS
Model:PE NexION 1000Main function :Suitable for the research of metal elements in chemistry, biology, medicine, and clinical samples. It can measure more than 80 elements at the same time, with high sensitivity, simultaneous multi-element rapid analysis, Suitable for trace or ultra-trace element analysis of complex systems (10-9~10-12g/L),such as research techniques for the control and analysis methodology of elemental impurities.
Ion Chromatography IC
Model:Thermofish ICS5000+（conductivity and amperometric detector）Main function :Widely used in the analysis and methodological studies of anions, cations, organic acids, organic amines, cyanide, sulfur ions, iodide ions, sugars and amino acids in samples from industries such as environment, materials, chemicals, food, biology, and medicine .
Triple quadrupole mass spectrometer LC-MS-MS
Model: Agilent 6410Main function :Suitable for screening and development of chiral compounds in chemistry, medicine, chemical industry, ee values, chiral purity determination. Provides a powerful method for the resolution of chiral compounds.
Chiral Sample Analysis
Model:Waters UPC2/8 column screening
Chiral Sample Analysis
Model:Shimadzu 20AD/12 column screeningMain function :Suitable for screening and development of chiral compounds in chemistry, medicine, chemical industry, etc., ee value, chiral purity determination, etc. Provide a powerful method for the resolution of chiral compounds.
Chiral split SFC
Model:SFC80/SFC150Main function :Suitable for the resolution of chiral compounds from mg to 100g in chemistry, medicine, chemical industry, etc.
Gas chromatography-mass spectrometer GC-MS
Model:Agilent 5977A
Model:Shimadzu GC-MS 2020
Main function :Suitable for environmental analysis, food, petrochemical industry, biomedicine, flavor and fragrance, forensic poison, tobacco and other industries. It can qualitatively and quantitatively detect and analyze small molecular organic compounds with low boiling point and good thermal stability, especially Suitable for low boiling point Methodological studies on trace impurities such as potentially genotoxic impurities.
Pre-LC
Model:Waters 2545-QDa150ml/min
Preparative chromatography
Model:Gilson 306 50ml/minMain function :Suitable for separation and purification of organic synthesis products of compounds in chemistry, medicine and chemical industry, analysis, preparation and separation of trace impurities in raw materials and preparations.
Other instruments :
Infrared Spectrometer
Model:PE Spectrum TWO
UV Spectrometer
Model: PE Lambda 365
Polarimeter
Model:Anton Paar MCP5300
Moisture Analyzer:
Model:METTLER TOLEDO V30S
Moisture Analyzer:
Model:METTLER TOLEDO c30S
Potentiometric titrator:
Model:METTLER TOLEDO T50
