Inflammatory immune diseases have gained much attention as the incidence has grown bigger each year. The diseases can affect many parts of human bodies and reduce the quality of life drastically. Yet the diagnoses can be frustrating and stressful because no one is sure what causes such diseases.
The preclinical pharmacology department of Medicilon has been deeply involved in this field for many years, and has provided a variety of stable and reliable animal models for different targets and pathways for the evaluation of inflammatory immune disease treatments in order for the successful clinical transformation.
At present, as the pathogenesis of inflammatory and immunological diseases is unclear, there are few effective therapeutic drugs available in clinical practice. In such a context, the appropriate preclinical research techniques and models are required to help companies and researchers further develop and evaluate new drugs. Our Preclinical Pharmacodynamics Department has been deeply involved in this field for years, developing reliable animal-based efficacy evaluation models aimed at different targets and pathways, thus facilitating the clinical transformation of new drugs.
RA is a chronic and systemic inflammatory autoimmune disease mainly targeting joints. It has a very high disability rate. The cause of the disease is still unclear.
Medicilon models that you can choose from:
CIA mice/rats Models
CFA rats Models
Major Endpoints
Foot Volume
△CIA Models △CFA Models
Arthritis Index
△CIA Models
Cytokine Expression
△CFA Models
Other arthritis models:
Carrageenan-induced acute arthritis mice/rats models
Uric acid sodium induced gouty arthritis rats models
"Leaky Gut" with Age Improved through Dietary Restriction
Altered Levels of Neonatal Inflammatory Markers Associated with Childhood Leukemia
Psoriasis is a common skin disease that occurs worldwide. It is a disease that is not only closely related to genetics, but also obviously related to the environment.
Medicilon establishes diverse models that captures key features of psoriasis, including:
IL-23 induced hyperplasia of auricle epidermis mice models
Imiquimod induced psoriasis mice models
Vaginal epithelial mitosis mice models
Tale exfoliation mice models
Major Endpoints:
Skin thickness
△Pathological skin change of Imiquimod induced psoriasis mice
Ear thickness
△Pathological skin change of IL-23 induced psoriasis mice
Skin colligation score of mice
△Pathological skin change of Imiquimod induced psoriasis mice
Pathological skin score
△Imiquimod induced psoriasis △IL-23 induced psoriasis
Atopic dermatitis is a chronic, recurring, inflammatory skin disease, often accompanied by other symptoms such as allergic rhinitis, asthma, eczema, etc. The cause of the disease is not yet clear and there is no cure.
The disease related models include:
DNFB induced chronic dermatitis mice models
DNFB & OX induced chronic dermatitis mice models
Phorbol ester induced acute eczema mice models
DNFB induced acute eczema mice models
Skin score
△DNFB induced chronic dermatitis
Skin thickness
△DNFB induced chronic dermatitis
Inflammatory bowel disease (IBD) is a group of unexplained chronic intestinal inflammatory diseases. Due to the increasing incidence, it has become a common digestive system disease in our country. It mainly refers to ulcerative colitis and Crohn’s Disease.
Our IBD models includes:
TNBS induced IBD rats models
DSS induced IBD mice models
△Colon length of TNBS induced IBD rats models
△Colon weight of DSS induced IBD mice models
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