Keeping pace with industrial development and market demand, Medicilon's experienced Pharmacology and Pharmacodynamics Department has established a complete animal model evaluation system based on verification, precise and efficacy testing. The test subjects we provide include non-human primates, dogs, rats, mice, rabbits, guinea pigs, and miniature pigs.
After 20 years of accumulation, Medicilon boasts 260+ evaluation models for non-tumor diseases, covering the inflammatory & immune diseases, CNS diseases, digestive diseases, , Metabolic diseases, cardiovascular diseases and other diseases.
We have a professional team with profound professional theoretical knowledge and many years of experimental experiences and have most of the advanced experimental facilities to comprehensively evaluate the efficacy of various categories of new drugs, evaluate the pharmacological and pharmacodynamic effects of various types of new drugs from druggability to Class I innovative drugs from the molecular level, cellular level, ex-vivo, in vivo. The pharmacology department has a professional team with profound professional theoretical knowledge and many years of experimental experience. Preclinical systematic efficacy evaluation can be conducted on multiple categories of drugs (including oral preparations, injections, topical preparations, nasal drops, sprays, etc.), including small molecule chemicals, ADC drugs, cell preparations, monoclonal antibodies, traditional Chinese medicine, etc. We can provide comprehensive and authentic trial data and research reports for new drug applications. It has been highly recognized by many customers in the industry.
69 Inflammatory & immune diseases models
64 CNS diseases models
18 Digestive diseases models
46 Metabolic diseases models
25 Cardio-vascular diseases models
45 Other diseases models
Data as of 2024.08
| Disease | Type | Species |
|---|---|---|
| Arthritis | Acute joint inflammation (Carrageenan induction) | Rat |
| Acute joint inflammation induced CFA | Mouse/Rat | |
| Rheumatoid arthritis induced by II Collagen (CIA model) | Mouse/Rat | |
| Rheumatoid arthritis induced by Complete Freund’s Adjuvant (AIA model) | Rat | |
| Gouty arthritis model induced by sodium urate | Rat | |
| Osteoarthritis | Sodium iodoacetate (MIA) induced osteoarthritis | Rat |
| Partial Medial Meniscectomy (pMMx) induced osteoarthritis | Rat | |
| Partial Medial Meniscectomy with Anterior Cruciate Ligament severed (pMMx + ACLT) osteoarthritis | Rat | |
| Osteoporosis | Osteoporosis model of castrated female rat | Rat |
| Osteoporosis model (Retinoic acid A induction) | Rat | |
| Osteoporosis model (Glucocorticoid induction) | Rat | |
| Psoriasis | Vaginal epithelium mitosis (Estrogen induction) | Mouse |
| Tail scale model | Mouse | |
| Auricle epidermal dysplasia (IL-23 induction) | Mouse | |
| Back skin psoriasis (Imiquimod induction) | Mouse/Rat | |
| Atopic dermatitis and eczema | Atopic dermatitis model (MC903 induction) | Mouse |
| Atopic dermatitis model (Oxazolone induction) | Mouse | |
| Chronic atopic dermatitis model (DNFB induction) | Mouse/Rat | |
| Chronic atopic dermatitis model (DNCB+OX induction) | Mouse | |
| Subacute eczema-like model induced by DNFB | Mouse | |
| Eczema-like model induced by Phorbol ester | Mouse | |
| Multiple sclerosis , Amyotrophic lateral sclerosis (MS，ALS） | EAE allergic encephalomyelitis model (EAE) | Mouse |
| Cuprizone-induced demyelination of brain tissue | Mouse | |
| Pulmonary inflammation and fibrosis | Pulmonary inflammation model (LPS induction) | Mouse/Rat |
| Systemic inflammation model (LPS induction) | Mouse/Rat | |
| Pulmonary fibrosis model (Bleomycin induction) | Mouse/Rat | |
| Pulmonary fibrosis model (Paraquat induction) | Rat | |
| Silicosis model (Silicon dioxide induction) | Mouse/Rat | |
| Asthma | Bronchial asthma model (OVA + Aluminum hydroxide induction) | Rat |
| Nephritis | Heymann nephritis model | Rat |
| IgA nephritis model | Mouse | |
| Serum sickness nephritis model | Rat | |
| Alopecia and Alopecia areata | Alopecia (Rosin and Paraffin + Testosterone propionate induction) | Mouse |
| Alopecia (Testosterone propionate induction) | Mouse/Rat | |
| Alopecia (Dihydrotestosterone induction) | Mouse | |
| Alopecia areata (Imiquimod induction) | Mouse | |
| Alopecia areata (Cyclophosphamide induction) | Mouse | |
| Allergic rhinitis | Allergic rhinitis model (OVA + Aluminum hydroxide induction) | Mouse |
| Allergic rhinitis model (OVA + DPT vaccine induction without cell) | Rat | |
| Pruritus model | Pruritus model (Chloroquine induction) | Mouse |
| Acute pruritus model (Histamine induction) | Mouse | |
| Pruritus model (Histamine + 4-AP induction) | Mouse | |
| Pruritus model (Dextran induction) | Mouse | |
| Acute pruritus model (Compound 48/80 induction) | Mouse | |
| Pruritus model (MC903 induction) | Mouse | |
| Dry skin pruritus model | Mouse | |
| Humoral and cellular immune function | Immunodeficiency model (Dexamethasone induction) | Mouse |
| Heteroprotein-induced immune dysfunction model | Mouse | |
| Cellular immune function test in vivo | Mouse | |
| Humoral immune function test in vivo | Mouse | |
| Avaluating effects on mononuclear macrophage function in vivo | Mouse | |
| Inflammation and Swelling | Auricle swelling model | Mouse |
| Toe swelling model | Rat | |
| Capillary permeability test | Mouse/Rat | |
| Granuloma proliferation model | Rat | |
| Carbon Clearance Test | Mouse | |
| Fever model (Yeast induction) | Mouse | |
| Passive cutaneous anaphylaxis (PCA) | Mouse/Rat | |
| Immune-mediated inflammatory eye diseases | Allergic conjunctivitis (AC) model | Rat |
| Dry eye model | Rat |
| Disease | Type | Species |
|---|---|---|
| Depression | Forced swimming test | Mouse/Rat |
| Tail suspension test | Mouse | |
| 5-HTP-induced head twitches response | Mouse | |
| Reserpine-induced ptosis | Mouse | |
| Yohimbine-induced lethality test | Mouse | |
| High-dose apomorphine antagonism | Mouse | |
| Chronic unpredictable mild stress (CUMS) | Rat | |
| Novelty suppressed feeding test | Mouse/Rat | |
| MAO-A/MAO-B activity test | Mouse/Rat | |
| Convulsant | Pentylenetetrazol-induced clonic seizure | Mouse |
| Bicuculline-induced clonic seizure | Mouse | |
| Yohimbine-induced lethality test | Mouse | |
| Picrotoxin-induced clonic seizure | Mouse | |
| Sedative hypnosis anti-anxiety | Synergistic effect with pentobarbital | Mouse |
| Synergies with pentobarbital drugs | Mouse | |
| Wake up and fall asleep again | Mouse | |
| Open field test (video monitoring, software processing) | Mouse/Rat | |
| Elevated plus maze test (video monitoring, software processing) | Mouse/Rat | |
| Shuttle Box test (video monitoring, software processing) | Mouse | |
| Schizophrenia | MK801 induced schizophrenia (positive/negative symptom) | Mouse |
| Ketamine induced schizophrenia with negative symptom | Mouse | |
| Haloperidol-induced catalepsy | Rat | |
| Lower lip retraction test | Rat | |
| Apomorphine-induced rotation test | Mouse | |
| Hyperactivity induced by amphetamine | Rat | |
| Hyperactivity induced by phencyclidine | Rat | |
| Parkinson’s Disease | Subacute model induced by MPTP | Mouse |
| Chronic model (MPTP + probenecid induction) | Mouse | |
| Oxotremorine-induced tremors/salivation | Mouse | |
| Nociceptive Pain | Hot- or cold-plate tests, Radiant heat tail-flick test, Randall-Selitto test | Mouse/Rat |
| Von-Frey filaments test | Mouse/Rat | |
| Acetic acid writhing test | Mouse | |
| Formalin model (phase I & phase II) | Mouse | |
| Model of foot inflammatory pain model induced by Complete Freund’s Adjuvant (CFA) | Mouse/Rat | |
| Model of foot inflammatory pain (Carrageenan induction) | Mouse/Rat | |
| L5/L6 spinal nerve ligation (SNL) | Rat | |
| LPS-induced thermal hyperalgesia | Mouse/Rat | |
| Sciatic nerve injury (SNI) model | Mouse/Rat | |
| Incision-induced pain model | Rat | |
| Diabetic foot ulcer pain model | Mouse/Rat | |
| Chemotherapy pain model (Vincristine induction) | Rat | |
| Chemotherapy pain model (Paclitaxel induction) | Rat | |
| Osteoarthritis pain model (pMMx + ACLT induction) | Rat | |
| Osteoarthritis pain model (MIA induction) | Rat |
| Diseases | Models | Animals |
|---|---|---|
| Gastric acid secretion and Gastric ulcer | Gastric ulcer model caused by pyloric ligation | Rat |
| Histamine induced gastric acid secretion model | Rat | |
| Gastric ulcer model (Ethanol induction) | Mouse | |
| Non-steroidal anti-inflammatory drug induced gastric ulcer model | Rat | |
| Gastric ulcer model induced by water bundle stress | Rat | |
| Chronic gastric ulcer model (Acetic acid induction) | Rat | |
| Gastric ulcer model induced by Pyloric ligation | Rat | |
| Duodenal mucosal lesions model (Cysteine induction) | Rat | |
| Reflux esophagitis model | Rat | |
| Chronic atrophic gastritis model | Rat | |
| Inflammatory Bowel Disease (IBD) | Ulcerative colitis model (TNBS induction) | Rat |
| Ulcerative colitis model (DNBS induction) | Rat | |
| Ulcerative colitis model (DSS induction) | Mouse | |
| Gastric and intestinal motility disorders | Gastric emptying (GE) model | Mouse/Rat |
| Gastric and intestinal motility model | Mouse/Rat | |
| Functional dyspepsia model | Rat | |
| Diarrhea model | Mouse/Rat | |
| Constipation model | Mouse/Rat |
| Disease | Type | Species |
|---|---|---|
| Obesity and Diabetes | Obesity model (HFD and HSD induction) | Mouse/Rat/Golden Hamster |
| DIO model (HFD induction) | Mouse/Rat | |
| Model of losing fat and gaining muscle | Mouse/Rat | |
| Type 1 diabetes model (Streptozotocin induction) | Mouse/NOD Mouse/Rat | |
| Spontaneous type 2 diabetes mice (db/db, ob/ob) | db/db Mouse, ob/ob Mouse | |
| Spontaneous type 2 diabetes rat (ZDF) | ZDF Rat | |
| Diabetic skin ulcer model | Mouse/Rat | |
| Diabetic foot model | Mouse/Rat | |
| Hyperuricemia | Hyperuricemia (Potassium oxonate induction) | Mouse/Rat |
| Hyperuricemia (Adenine induction) | Rat | |
| Hyperuricemia (Adenine + Potassium oxonate induction) | Rat | |
| Hyperuricemia (Hypoxanthine induction) | Mouse | |
| Hyperuricemia (Hypoxanthine + Potassium oxonate induction) | Mouse/Rat | |
| Hyperuricemia (Yeast induction) | Mouse | |
| Hyperuricemia (Adenine + Ethambutol induction) | Rat | |
| Hyperuricemia (Uric acid induction) | Mouse | |
| Liver Fibrosis | Liver fibrosis model (Biliary ligation induction) | Rat |
| Liver fibrosis model (TAA induction) | Rat | |
| Liver fibrosis model (Composite factor induction) | Rat | |
| Liver fibrosis model (ConA induction) | Mouse | |
| Immune liver fibrosis (pig serum induction) | Rat | |
| Liver and Bile duct diseases | Acute liver injury model (Acetaminophen induction) | Mouse |
| Intrahepatic cholestasis model | Rat | |
| Primary biliary cholangitis | Mouse | |
| NAFLD（NAFL / NASH） | Alcoholic liver injury model | Mouse/Rat |
| HFD diet induced NAFLD model | Mouse/Rat/Hamster | |
| HFD diet induced NASH model | Mouse/Rat/Hamster | |
| MCD diet induced | Mouse | |
| CDAA diet induced | Mouse/Rat | |
| Composite factor induced | Rat |
| Disease | Type | Species |
|---|---|---|
| Dyslipidemia | Hyperlipidemia model (HFD/Cholesterol /Fructose diet induction) | Rat/ Hamster |
| Hereditary atherosclerosis+HFD | APOE Mouse | |
| Thrombosis, Anticoagulation, Hemophilia | Arteriovenous bypass thrombosis model | Mouse/ Rat |
| Caudal vein thrombosis (Carrageenan induction) | Mouse | |
| Rat model of deep vein thrombosis | Rat | |
| Carotid artery thrombosis model | Mouse/Rat | |
| Bleeding time (BT) test | Mouse | |
| Coagulation time (CT) test | Mouse | |
Four tests for coagulation (PT, APTT, TT, FIB) | Mouse/Rat | |
| F8-KO hemophilia model | Mouse | |
| Middle Cerebral Artery Occlusion(MCAO) | Cerebral ischemia reperfusion: dose-dependent and time-effect relationship research | Mouse/Rat |
| Time window for treatment of cerebral ischemia reperfusion injury | Mouse/Rat | |
| The neuroprotective effect of cerebral ischemia reperfusion | Mouse/Rat | |
| Permanent cerebral infarction model | Rat | |
| Myocardial ischemia-reperfusion | Myocardial ischemia-reperfusion model | Rat |
| Anemia | Hypoferric anemia | Rat |
| Renal anemia induced by 5/6 Nephrectomy | Rat | |
| Renal anemia induced by adenine | Rat |
| Disease | Type | Species |
|---|---|---|
| Kidney injury and failure | Acute renal failure (Cisplatin induction) | Rat |
| Rhabdomyolysis-induced acute kidney injury (RIAKI) model | Mouse | |
| Renal ischemia-reperfusion model | Rat | |
| Chronic renal failure induced by 5/6 Nephrectomy | Rat | |
| Chronic renal failure induced by Adenine | Rat | |
| Diabetic renal failure | ZDF Rat，db/db Mouse | |
| Renal fibrosis model | Rat | |
| Skin Healing | Full-thickness skin trauma model | Mouse/Rat |
| Diabetic foot ulcer model | db/db Mouse | |
| Standardized Scalding Burn Model | Mouse/Rat | |
| Leukopenia | Leukopenia model (Cyclophosphamide induction) | Mouse/Rat |
| Leukopenia model (Cytarabine induction) | Rat | |
| Leukopenia model (Adriamycin induction) | Rat | |
| Leukopenia model (Cisplatin induction) | Rat | |
| Prostatic Diseases | Tracheal goblet cell staining counts | Mouse/Rat |
| Prostatic hyperplasia model (Castration) | Mouse/Rat | |
| Prostatic hyperplasia induced by Androgen | Mouse/Rat | |
| Nonbacterial prostatitis | Rat | |
| Respiratory system | Expelling phlegm test (phenol red excretion method) | Mouse |
| Tracheal goblet cell staining counts | Rat | |
| Sexual dysfunction | Erectile function test in normal rat | Rat |
| Erectile function test in castrated rat | Rat | |
| Sexual behavior test experiment (Back climbing experiment) | Rat | |
| Gynecological disease | Mammary hyperplasia model | Rat |
| Uterine fibroid model | Rat | |
| Endometriosis model | Mouse/Rat | |
| Hyperthyreosis | Secondary hyperthyroidism model | Mouse/Rat |
| Sepsis | Sepsis model (LPS induction) | Mouse |
| Sepsis model (CLP induction) | Mouse | |
| Ocular disease | Glaucoma Model | Rat |
| Choroidal Neovascularization (CNV) Model | Mouse/Monkey | |
| Retinal Neovascularization (RNV) Model | Rabbit | |
| Alkali Burn of Cornea Model | Rat/Rabbit | |
| Dry AMD Model | Mouse |
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