Medicilon Drug Screening Services: Gifts for Summer Events

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2022-05-13

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Medicilon cares for DMPK features in the early-stage. The early stage DMPK tests generates less cost and yet may produce crucial results, providing insights for the whole R&D projects. In order to express our appreciation for our clients for trust and support, Medicilon launched the colorful SUMMER EVENTS, involving pharmacokinetics services for drug screening (non-declaration).

Contents

Date: Now—June 30, 2022

GIFT 1

For new clients, first DMPK test order FREE.

❖ ICR mice

❖ SD rats

GIFT 2

DMPK Screening discount up to 20%.

(Animal species: ICR mice, SD rats, Non-naïve Beagles, Non-naïve cynomolgus monkeys)

Compound #	6-10	10-20	>20
Discount	10%	15%	20%

Experiment Cases

Species	Dosing	24-hour blood collection	Animals #	Experimental period
ICR mice	Single-dose, intravenous and oral	6	6	1-2 weeks
		6-10
SD rats		8-10
Beagles
cynomolgus monkeys

*The final interpretation right of this event belongs to the Marketing Department of Medicilon

Drug Screening

The DMPK test reveals the ADME features in vivo of drug compounds and their metabolites. These results can provide crucial evidence for pharmacology and toxicology research and generate reasonable deductions. Meanwhile, many parameters in later research are set based on these results.

Medicilon is amply experienced in DMPK research. We are capable of providing R&D services of chemical compounds, biotech macromolecules and advanced biotech therapies with high quality and efficiency. Our services span from ADME screening in vitro to animal tests in vivo.

ADME in vitro

❖ Plasma protein binding

❖ Tissue protein binding

❖ Blood to plasma ratio

❖ Plasma stability

❖ Microsomal stability

❖ Hepatocyte stability

❖ CYP reaction phenotype

❖ Cytochrome 450 inhibition (TDI)

❖ Cytochrome 450 Induction

❖ Caco-2 permeability

❖ Transporter test

❖ Drug-drug interaction

❖ Metabolite profiling & identification

❖ Metabolic pathway profiling & identification

❖ More details about"ADME in vitro"

PK in vivo

❖ Hemodynamics study

❖ Tissue distribution study

❖ Excretion mass balance study

❖ Blood brain barrier permeability

❖ Metabolite in vivo profiling & identification

❖ Isotopic DMPK study

❖ Isotopic tissue distribution test

❖ Isotopic mass balance study

❖ Polypeptide DMPK test

❖ PROTAC DMPK test

❖ ADC/PDC DMPK test

❖ Oligonucleotide DMPK test

❖ mRNA vaccine DMPK test

❖ Cellular immunotherapies DMPK test

❖ More details about "PK in vivo"

Advanced instrumentation and equipment

❖ MSD SECTOR Imager 6000

❖ Luminex Bio-Plex 200

❖ Gyrolab xPlore

❖ Molecular Devices SpectraMax Plate Readers

❖ Bio Tek ELx405 Plate Washer

❖ Applied Biosystems 7500 Real-Time PCR System

❖ Thermo NanoDrop

❖ Perkin Elmer EnVision Plate Reader

❖ Biacore 8K

❖ Hamilton Workstation

❖ Thermo KingFisher Flex

❖ Covaris E220 AFA

❖ ...

E-mail:marketing@medicilon.com

Address:
585 Chuanda Rd, Pudong, Shanghai, China, 201299 (Headquarters）
1 Broadway, 9th Fl, Cambridge Innovation Center, Cambridge, MA 02142, US
Kelvinstraat 41b, 6601 HH Wijchen, The Netherlands
Allia Future Business Centre Kings Hedges Road Cambridge CB4 2HY, UK

Drug-Screening ADME-in-vitro PK-in-vivo

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