Recent interest in the delivery of therapeutics to the brain has dramatically increased with the advent of new antibody drug conjugates (ADCs) and other targeted delivery vehicles for the treatment of dementias and glioblastoma. In addition, subcutaneous delivery has been found to be an effective mode of ADC delivery, but the bioavailability in humans has been difficult to predict. These two factors have driven an increasing interest in the human cell-based in vitro models for screening novel delivery methods to gain mechanistic insight into the factors that control either entry into the brain or systemic bioavailability of subcutaneously delivered drugs. In this presentation Dr. Roger Kamm will present the models specifically developed for both applications and the potential for iPS cell-derived systems. The benefits and current limitations of these models will also be addressed with the goal of stimulating an active discussion.
During the NEDMDG 2024 Spring Meeting, Dr. Roger Kamm, Depts. of Biological Engineering and Mechanical Engineering at MIT will give this wonderful presentation.
The Seminar is Sponsored by Medicilon.
Date: Wed. March 13th, 2024 at 5:30 - 8:30 pm EST
Location: Agios Pharmaceuticals, 88 Sidney St., Cambridge, MA 02139