Non-Tumor Disease Mouse Model Services
Boston Based Non-Tumor Disease Mouse Model
Start Your Boston In Vivo Study
Non-Tumor Disease Mouse Model Platform at Boston site
The Boston site provides access to 14+ validated mouse models covering immunology, dermatology, inflammation, respiratory disease, autoimmunity, colitis, fibrosis, and more. These models include multiple endpoints such as PASI scoring, cytokine panels, H&E staining, Sirius Red, flow cytometry, ELISA, colon length, lung infiltration scores, and organ weight measurements, all based on the validated workflows documented in the platform deck.
Fast Study Startup
Boston location enables rapid project onboarding for U.S.-based sponsors.
Deep Mechanistic Readouts
Histology (H&E, PAS, Sirius Red), cytokines, ELISA, flow cytometry, biomarkers.
Strong Translational Value
Models reflect human immunological and pathological mechanisms:
- Th1/Th17 (TNBS, CIA, EAE)
- Th2 (OVA, HDM, MC903)
- Innate inflammation (DSS, MSU)
Customizable Study Designs
Endpoints, dosing regimens, timelines, and biomarker selections tailored for your mechanism of action.
Experienced Immunology Team
Expert in vivo immunologists supporting study design, interpretation, and reporting.
Featured Validated Non-Tumor Disease Models
At Medicilon, we go beyond standard modeling. we deliver scientifically rigorous, customizable solutions that help de-risk early-stage and IND-enabling development.
Non-Tumor Disease Model Portfolio
Model Name
Category
Disease Area / Mechanism
Key Readouts / Endpoints
Dermatology
TLR7/8-mediated inflammation
PASI score, dorsal thickness, TNF-α, H&E, spleen weight
Dermatology
Th2/Th17-driven dermatitis
IgE, TNF-α, IL-1β, IL-6, IP-10, H&E, skin thickness
Dermatology
Autoimmune melanocyte destruction
Depigmentation scoring, skin histology, immune infiltration
Autoimmune & Systemic Disease
TLR-mediated lupus autoimmunity
Anti-dsDNA, spleen weight, renal pathology (C3, PAS)
Autoimmune & Systemic Disease
Autoimmune arthritis (Th17)
Clinical score, paw thickness, IL-17, TNF-α, joint histology
Autoimmune & Systemic Disease
CNS autoimmunity (MS-like)
0–5 neurological scoring, spinal cord histology
Gastrointestinal / IBD
Acute innate colitis
DAI, colon length, H&E, body weight loss
Gastrointestinal / IBD
Th1/Th17 Crohn’s-like disease
Body weight, colon length, H&E inflammation
Gastrointestinal / IBD
Chronic T cell–driven colitis
Lipocalin-2, colon length, crypt damage, immune infiltration
Respiratory & Allergy
Natural allergen-induced Th2/Th17 inflammation
BALF eosinophils, IgE, cytokines (IL-1β, IL-6), mucus, H&E
Respiratory & Allergy
Th2-mediated airway inflammation
IgE (BALF/serum), eosinophils, TNF-α, IFN-γ, IL-1β, histology
Fibrosis Models
Lung fibrotic remodeling
BALF immune cells, collagen (Sirius Red), H&E
Fibrosis Models
Myocardial fibrosis
Sirius Red collagen staining, H&E, heart weight changes
Acute Inflammation
Acute innate neutrophilic inflammation
TNF-α, IL-1β, IL-6, KC, MCP-1, neutrophils in lavage/blood
What We Deliver
At Medicilon, we do more than perform standard modeling—we apply a deeply scientific, evidence-based approach that integrates rigorous experimental design, validated analytical frameworks, and customizable study parameters. This enables us to generate high-resolution, reproducible datasets that improve mechanistic understanding, strengthen predictive accuracy, and substantially de-risk both early-stage drug development and IND-enabling programs. Through these enhanced processes, we help sponsors advance candidates with greater confidence and scientific clarity.
- Complete study plan & protocol
- In vivo execution & monitoring
- Cytokines, IgE, ELISA, flow cytometry, histopathology
- Statistical analysis & full reporting
- Scientific consultation from start to finish
Launch Your Non-Tumor Mouse Model Study Today
Frequently Asked Questions
Have questions about Non-Tumor Model Studies?
What types of non-tumor disease mouse models does Medicilon’s Boston site offer?
Medicilon’s Boston site provides more than 14 validated non-tumor disease mouse models, including psoriasis, atopic dermatitis, lupus, colitis, IBD, arthritis, asthma, pulmonary fibrosis, peritonitis, cardiac fibrosis, and neurological autoimmune disease (EAE). These models are supported by histology, cytokine profiling, flow cytometry, biomarkers, and imaging.
Can I customize the study design for my therapeutic program?
Yes. Study design, dosing strategy, endpoints, biomarkers, and sampling frequency are all fully customizable. Our Boston immunology team provides scientific consultation to align the model with your target, MoA, or regulatory needs.
What types of analytical readouts can Boston site support?
The site supports: • Histopathology: H&E, PAS, Sirius Red • Cytokines & Biomarkers: TNF-α, IL-1β, IL-6, IP-10, dsDNA, lipocalin-2, IgE levels • Flow Cytometry: eosinophils, CD4/CD8 T cells, neutrophils, macrophages • Clinical Endpoints: PASI scoring, DAI scoring, paw swelling, airway inflammation • Organ Metrics: spleen weight, colon length, heart fibrosis, lung infiltration These are all derived from the validated protocols in the Boston platform.
How quickly can a study start at the Boston site?
Medicilon Boston supports rapid study start-up, often within 1-2 weeks, depending on availability, protocol complexity, and animal sourcing. The U.S. location supports fast communication with U.S. sponsors.
Which models are best for screening anti-inflammatory or immunomodulatory agents?
• DSS colitis (innate inflammation) • TNBS IBD (Th1/Th17-driven) • MC903 atopic dermatitis (Th2/Th17) • IMQ psoriasis (TLR7/8-mediated) • CIA arthritis (Th17 autoimmunity) • EAE (neuroinflammation model) Models can be chosen based on target biology.
Does Medicilon Boston offer chronic disease models?
Yes. Chronic models include: • Adoptive T-cell IBD (4-10 weeks) • EAE, depending on progression • Chronic HDM asthma • Bleomycin-induced fibrosis (multi-week) These models support long-term therapeutic evaluation.
What validation data is available for the models?
Each model includes: • Dose timelines • Clinical scoring curves • Biomarker data • Histopathology examples • Flow cytometry or ELISA panels All validation data is derived from the platform PDF you shared.
Can I include multiple endpoints in a single study?
Absolutely. Most clients combine: • Histology + cytokines • Histology + flow cytometry • Biomarkers + disease scoring • PK + efficacy Our team recommends endpoint combinations based on therapeutic class.
Does Boston site support both small molecules and biologics?
Yes. Models support small molecules, antibodies, peptides, RNA therapeutics, and cell therapies - with custom formulation or route-of-administration options.
Does Medicilon provide full reporting and regulatory-ready data?
Yes. Upon completion, you’ll receive: • A full scientific report • Raw data • Statistical analysis • Histology and imaging files • Method details These reports are suitable for internal decision-making and regulatory documentation.
