Contact Us marketing@medicilon.com
Medicilon Logo
|
search icon search icon contact icon menu icon
Medicilon Logo
|
search icon close search icon contact icon menu icon
Message
Contact Us
Close Button
Back To Top
Online Message×
Click switch
Close Button
FAQs

Types of Early DMPK Studies

Protein binding: plasma, brain tissue, microsomal protein, FBS; Erythrocyte /plasma partition ratio

Optimization permeability and transport: Caco - 2. MDCK - MDR1 / BCRP, OATs/OCTs/OATPs

In vitro metabolic DDI: P450 inhibited TDI, P450 induced /PXR, metabolic enzyme phenotype.

Metabolic stability: microsomes, S9, hepatocytes, plasma, whole blood 

Metabolite Screening and Identification: in vitro, in vivo, and GSH Trapping 

In vivo PK: rat, mouse, dog, monkey, pig, rabbit box/single administration

Routes of administration: IV/IJVC/SC/TD/IM/IP/PO/SL/IN/IVT 

Continuous cross/single point blood sampling 

BBB(homogenate /CSF), Tissue distribution excretion (BDC), in vivo DDI (ABT)