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FAQs

Why Choose a Thermodynamically Stable Crystal Form for Development?

Without the influence of solvent and humidity, a polymorph that is thermodynamically stable at room temperature is the only form guaranteed to not convert to another polymorph.

The disadvantage of the thermodynamically stable form is that it always has the lowest solubility among polycrystalline forms and the lowest potential bioavailability. However, in most cases, this is a small price to pay for the significant advantage of absolute dynamic stability.

The solubility difference between various polymorphs is usually less than twice, but sometimes up to five times of difference can be observed. If there are several corresponding correlation forms and the transition temperature is near room temperature, the selection may be difficult.

• Based on the standard "same for all solid forms," the dynamics of interconversion of forms and the reproducibility of consistently producing the same proportion of polymorphs are important.