This site uses cookies and related technologies, as described in our privacy policy, for purposes that may include site operation, analytics, enhanced user experience, or advertising. You may choose to consent to our use of these technologies, or refuse these technologies

Drug Discovery

Chemistry Research Biology Research Early Pharmacokinetics Enzyme Catalytic Platform 3D Cultured Spheroid Models Cell Viability Assay SPR Assay In Vitro Enzyme Activity Assay Carbohydrate Chemistry Continuous Flow Chemical Technology Isotope-labeled Internal Standards Synthesis Fluorescence Probes Synthesis Peptide Synthesis Anti-drug Antibody Preparation Hybridoma Technology Nanobody Preparation Radiolabel ADME Catalyst Screening Coagulation Pathway Studies In Vitro Single B Cell antibody discovery technology Fee For Service(FFS) Full-Time Equivalent(FTE) Antibody Development Technology Service
Pharmaceutical Research

Intermediates Active Pharmaceutical Ingredients Pharmaceutical preparation Analytical Method Development and Quality Control CMC Filings Analytical Testing Center Bacterial Endotoxin Test Preformulation Study Formulation Technology Research Preparation Quality Research Laboratory-scale Preparation Testing Pilot-scale Preparation Testing GMP-based Clinical Sample Production & Packaging Formulation Stability Study Consistency Evaluation
Preclinical Research

Pharmacology & Pharmacodynamics Drug Safety Evaluation DMPK Bioanalysis IND Filings Reproductive Toxicity Genotoxicity Study General Toxicology PDXO Models Cardiovascular Model Ocular Diseases Models CDX Models Macromolecular Drugs Bioanalysis Micromolecular Drugs Bioanalysis In Vitro ADME Assays In Vivo Pharmacokinetic Assays Safety Pharmacology Histopathological Study Clinicopathological Study Drug Safety Evaluation Basic Information Toxicokinetics GEM Models Humanized Mouse Models Syngeneic Mouse Models Digestive System Disease Models

FAQs

Home FAQs

Why Choose a Thermodynamically Stable Crystal Form for Development?

• Without the influence of solvent and humidity, a polymorph that is thermodynamically stable at room temperature is the only form guaranteed to not convert to another polymorph.

• The disadvantage of the thermodynamically stable form is that it always has the lowest solubility among polycrystalline forms and the lowest potential bioavailability. However, in most cases, this is a small price to pay for the significant advantage of absolute dynamic stability.

• The solubility difference between various polymorphs is usually less than twice, but sometimes up to five times of difference can be observed. If there are several corresponding correlation forms and the transition temperature is near room temperature, the selection may be difficult.

• Based on the standard "same for all solid forms," the dynamics of interconversion of forms and the reproducibility of consistently producing the same proportion of polymorphs are important.