What are features of an ideal DMPK?

Question

Accepted Answer

(1) Complete absorption (preferably passive absorption), bioavailability > 50% and minimal variation;

(2) AUC is proportional to dose, and there is a clear PK/PD correlation;

(3) Quickly reaches the target organ and do not accumulate outside it;

(4) PPB < 90%, unaffected by concentration and time;

(5) Plasma clearance CL < 30% of Q_h, cleared through various routes;

(6) Age, race, gender, disease state, etc. have little effect on CL; low quantity of metabolites and no production of reactive metabolites;

(7) metabolite quantity is low and no reactive metabolites are produced;

(8) Does not inhibit or induce major drug metabolizing enzymes and transporters, and is not affected by food;

(9) T_1/2>6hr in human body, reducing the dosing frequency and improving compliance.