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In July 2007, the United States FDA issued technical guidelines for generic drug crystal research, clarifying that polymorph includes crystals, amorphous forms, as well as solvates and hydrates, described as follows:
(1) In the crystalline state, molecules have different arrangements or conformations within the lattice;
(2) In the amorphous state, molecules lack regular arrangement and do not form identifiable lattice;
(3) Solvates contain equivalent or non-equivalent solvents within the crystal lattice. When water is the solvent, it is typically referred to as a hydrate.