What is Preclinical PK Analysis Method?

Question

Accepted Answer

• Noncompartmental Analysis (non-compartmental model):

The simplest and most objective method, providing parameters (t_1/2,Vd, CL, C_max, T_max, MRT, AUC_0-t. AUC_0-∞, etc.) that meet the IND declaration requirements. However, it cannot be used for prediction and simulation, and is based on linear PK assumptions;

• Traditional Compartmental PK Model:

Relatively simple and easy to use, capable of fitting non-linear PK data. It can be used for prediction and simulation, aiding in experimental design;

• Population PK Model:

More suitable for sparse data and covariate analysis (NONMEM/Monolix).