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FAQs

FAQs
Preclinical Research Animal Models of Commonly Used CAR-T Cell Products
​a) Syngeneic Mouse model with a complete immune system;b) Transgenic Mouse with a normal immune system;c) Human Xenograft Mouse Model;d) Humanized Immune System (HIS) Mouse Model
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What is Car-T Cell Therapy?
CAR-T immunotherapy (Chimeric Antigen Receptor T-cell Therapy) refers to the transfer of genetic material encoding specific antigen recognition domains and T cell activation signals into T cells through gene modification technology. This enables T cells to recognize and bind to specific antigens present on the surface of tumor cells, activating them to directly kill tumor cells by releasing perforins, granzyme B, etc. Additionally, CAR-T cells recruit endogenous immune cells by releasing cytokines, enhancing the immune system's ability to target and kill tumor cells. This approach aims to treat tumors effectively and can also establish memory T cells for sustained, specific anti-tumor effects.
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What are Trends in ADC Development?
In the first generation of ADC drugs, anticancer drugs mainly bind to mouse monoclonal antibodies through non-degradable linkers.
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COVID-19 Prevention and Treatment
Prevention:1. DNA vaccine 2. RNA vaccine 3. protein vaccine 4. viral vector vaccine Treatment: 1. Antibody therapy 2. Cell therapy 3. Nanotherapy 4. siRNA therapy
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What are Common Polypeptide Instabilities?
Easy degradation Thermal instability Oscillation instability Instability in acidic conditions Instability in alkaline conditions Freeze-thaw instability Unstable conformation Unstable storage under freezing conditions Unstable molecular interactions
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The Advantage of Polypeptides as Drugs
The Advantage of Polypeptides as Drugs
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What is the Difference Between NAFL and NASH?
NAFL: It is completely reversible and can be reversed through diet control, exercise and other healthy lifestyles. Drug therapy mainly aims to improve lipid metabolism.
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What are the Most Common Autoimmune Diseases?
Autoimmune diseases are a group of disorders characterized by the body's immune response mistakenly causing autologous tissue damage in response to self-antigens. Common examples include rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), inflammatory bowel disease (IBD), psoriasis, and atopic dermatitis.
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What is Pharmacodynamics Testing?
Pharmacodynamics testing reflects the main pharmacological effects and mechanisms of action of drugs according to drug classification and their pharmacological characteristics. This is achieved through appropriate in vitro and in vivo models, providing a basis for the development of new drugs and practical support for clinical research.
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What are the Advantages and Disdvantages of RNA?
RNA: by degrading target mRNA
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