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FAQs

FAQs
Typical Characteristics Affecting Bioanalysis
Not too small or large molecular weight Semi-antigenic properties
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Common Platform for Polypeptide Drug Bioanalysis
LC-MS/MS Ligand Binding assays: EIA, FIA, ECL, RIA, CLIA, etc
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Key Aspects of Polypeptide Drug Bioanalysis
​PK, TK ADA
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What are Advantages of Peptides?
Advantages and Features Significant activity, strong specificity, good receptor affinity, low toxicity, generally not prone to accumulation in the body.
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Where do Polypeptides Come From?
•Natural extract peptides: such as bone peptides •Chemical synthesis: exenatide, natriuretic peptide, Bremelanotide (2019.6), Afanotide (2019), etc.
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What are Polypeptides?
A peptide consists of two linked amino acids, whereas a polypeptide, as discussed here, typically contains fewer than 100 amino acids. Many therapeutic peptides consist of between 10 and 100 amino acid molecules.
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What is New Drug Development for Diabetes?
Ultra-short-acting insulin,Short-acting insulin ,Intermediate-acting insulin,Long-acting insulin
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What is a JAK inhibitor?
Small molecule drugs targeting JAKs. Various small molecule inhibitors have been developed for applications in autoimmune diseases. Based on their selectivity and different targets, they can be categorized as non-selective, selective, and compound types.
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What are PK Characteristics of Monoclonal Antibodies and Small Molecule Drugs?
Traditional small molecule drugs:Tissue penetration: Usually very good;Binding: usually contains distributions;Degradation: Metabolic degradation;Renal elimination: Usually very important , and so on.
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What is in vivo PK Study?
BA method development + PK pre-experiment + BA method validation Determine a reasonable calibration range, examine the interference and stability in the actual sample, and optimize the blood sampling time point (3 points near tmax at least; time points in the absorption phase, ast3 *t/2 or Clast 1/10 Cmax)
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