1) Understanding the structural boundaries associated with oral absorption
2) Identifying/determining the cause of poor oral bioavailability within a compound family
3) Using in vitro screening methods
4) The oral administration formula should enhance compound dissolution, and maintain them in a dissolved state at all times; non-precipitating solutions maximize the bioavailability of compounds limited by solubility or dissolution
5) The formulation should be as simple as possible to increase the probability of successful development.
6) For lead compounds that are needed to improve bioavailability, problem-solving strategies should focus to formulation or chemical approaches in parallel
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