What is the Difference Between NAFL and NASH?

Q: What is the Difference Between NAFL and NASH?

NAFL: It is completely reversible and can be reversed through diet control, exercise and other healthy lifestyles. Drug therapy mainly aims to improve lipid metabolism. NASH: It is a progressive form of nonalcoholic fatty liver disease, characterized by a metabolically stressful liver injury closely associated with insulin resistance and genetic predisposition. NASH can advance to cirrhosis and hepatocellular carcinoma and is also significantly associated with an increased risk of cardiovascular disease. The etiology of NASH is complex, and its exact pathogenesis is unknown. Currently, there is no specific treatment or drug therapy for NASH. Therapeutic drugs targeting different targets in NASH have become one of the current hotspots in research and development, focusing on various pathogenic mechanisms of NASH such as liver metabolism, inflammation, oxidative stress, fibrosis, etc.

Question

Accepted Answer

NAFL:

It is completely reversible and can be reversed through diet control, exercise and other healthy lifestyles. Drug therapy mainly aims to improve lipid metabolism.

NASH:

It is a progressive form of nonalcoholic fatty liver disease, characterized by a metabolically stressful liver injury closely associated with insulin resistance and genetic predisposition. NASH can advance to cirrhosis and hepatocellular carcinoma and is also significantly associated with an increased risk of cardiovascular disease.

The etiology of NASH is complex, and its exact pathogenesis is unknown. Currently, there is no specific treatment or drug therapy for NASH.

Therapeutic drugs targeting different targets in NASH have become one of the current hotspots in research and development, focusing on various pathogenic mechanisms of NASH such as liver metabolism, inflammation, oxidative stress, fibrosis, etc.