Business Inquiry
Global:
Email:marketing@medicilon.com
+1(781)535-1428(U.S.)
0044 7790 816 954 (Europe)
China:
Email: marketing@medicilon.com.cn
Tel: +86 (21) 5859-1500
• The solubility and bioavailability of stable crystals are too low
• A fast-release agent with a high dissolution rate is required
• Polycrystalline forms also exhibit different mechanical properties, such as hardness, powder fluidity, compressibility, and bonding strength. A well-known example is Acetaminophen, where the thermodynamically stable form (monoclinic form 1) cannot be pressed into a stable tablet. In contrast, metastable form 11 (orthorhombic form) can be pressed because it exhibits more favorable properties in terms of plastic deformation. In rare cases, this may lead to a decision to develop metastable forms.
• Manufacturing difficulty
• IP issues
• Chemical instability of thermodynamically stabilized crystals due to topological chemical factors