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Crystallization Methods

1. Evaporative crystallization
The solvent is removed by evaporation, changing the solution from unsaturated to saturated, and then precipitating the supersaturated solute as crystals.

2. Cooling crystallization
Cooling the solution to create a supersaturated solution
Applicable to substances whose solubility significantly decreases with temperature reduction.

3. Recrystallization
The process of recrystallizing crystals from a solution or melt after they have been dissolved in a solvent or melt.
Used for purifying APIs

4. Precipitation crystallization
Rapid crystallization, encompassing processes such as reaction crystallization and salt crystallization (including solvent-out crystallization)
Achieved through supersaturation by liquid mixtures, such as adding a third component like a precipitant, diluent, reactant, etc.