The cassette dosing regimen is an experimental strategy proposed by Berman J et al. in 1997: n drugs are mixed and administered to animals, while the in vivo concentrations of these compounds are measured and their pharmacokinetic parameters are calculated. This method has significant advantages: it reduces the number of samples, improves throughput, and avoids individual differences. At the same time it has obvious disadvantages: it increases the difficulty of the analytical method and increases the possibility of drug-drug interactions.
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