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FAQs

What are the main non-clinical safety risks associated with cell therapy, such as CAR-T cells?

The non-clinical safety risks of cell therapy (such as CAR-T cells) mainly include:

1. Cytokine release syndrome (CRS)
2. Graft-versus-host disease (GVHD)
3. Reversible neurotoxicity
4. Reduction of B cells
5. On-target/off-tumor
6. Tumorigenicity/tumorigenicity