• Feasibility
Whether the adopted process route can produce the target compound
Whether the reaction conditions can meet the requirements of the industrial process route for raw materials, equipment, and reaction conditions in the commercial production
Resolution of waste management issues
• Controllability
Good reproducibility
Consistency in product quality between batches, meeting expected quality standards
• Rationality
Raw materials: readily available
Selection of solvents and reagents: Preferably low toxicity, in accordance with ICH guidelines
EHS: Environmental protection and labor protection comply with laws and regulations
Cost: Competitive