Business Inquiry
Global:
Email:marketing@medicilon.com
+1(781)535-1428(U.S.)
0044 7790 816 954 (Europe)
China:
Email: marketing@medicilon.com.cn
Tel: +86 (21) 5859-1500
RNA: by degrading target mRNA
Advantage:
Can be delivered to cross the cell membrane
Can achieve high potencies for their targets
siRNA molecules tend to exhibit longer persistence of target mRNA knockdown.
Disadvantage:
High metabolic instability
Off-target effects
Poor cell permeability
Low bioavailability, Hepatotoxicity, poor PK and limited tissue distribution, poor solubility and stability, primarily targets liver diseases