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FAQs

FAQs
What are the main non-clinical safety risks associated with cell therapy, such as CAR-T cells?
The non-clinical safety risks of cell therapy, such as CAR-T cells, mainly include potential for tumorigenicity, immunogenicity, and off-target effects.
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How to address the issue of instability of nucleic acid drugs within the body?
Oligonucleotide drugs are unstable in the body, easily degraded by nucleases in circulation, and cleared through the kidneys with a short half-life.
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Why is pharmacokinetics (PK) considered a challenge in the development of oligonucleotide drugs?
Pharmacokinetics (PK) poses a challenge in the development of oligonucleotide drugs due to several reasons.
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What is PDXO Model?
PDX-derived organoid or PDXO model is an in vitro model that inherits most of the advantages of PDX models.
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What is PDX Model?
Patient-derived xenograft or PDX model is now recognized as the good in vivo model for predicting clinical outcomes.
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What are Inhaled Liquid Formulations and What do They Include?
Inhaled liquid formulation is an oral inhalation dosage form, referring to liquid formulations for nebulizers that produce continuous aerosol solutions for inhalation or suspension, etc.
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What is Inhalation Formulation?
Inhalation formulation refers to formulations in which a drug is delivered to the respiratory tract and/or lungs in the form of a mist through a specific device for local or systemic action.
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What is the Classification of Therapeutic Approaches in Immunotherapy?
1.Passive immunity [acts on tumors] • Anti-tumor monoclonal antibodies targeting EGFR, Her2 • Adoptive immunotherapy adoptive cell transfer, CAR-T
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What is the List of ADC Payload?
(1) 5-substituted 2' -deoxyuridine analogues (e.g., Avodine) (2) Nucleoside analogs (e.g. Entecavir) (3) Pyrophosphate analogs (e.g., Sodium terephthalate) (4) NRTI drugs (e.g. Lamivudine) (5) NNRTIs (e.g., Nevirapine) (6) Protease inhibitors (e.g., Gezoprevir) (7) Integrase inhibitors (e.g., Dolutegravir) (8) Entry inhibitors (e.g., Enfuvirtide) (9) Acyclic guanosine analogs (such as Guanidine) (10) Acyclic nucleoside ester analogs (such as Adefovir dipivoxil) (11) HCV NS5A and NS5B inhibitors (e.g., Sofosbuvir). (12) Influenza virus inhibitors (e.g., Peramivir) (13) Interferons, immune stimulators, oligonucleotides, and anti-mitotic inhibitors
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What are Potential Causes of Polypeptide Instability?
• Deamidation • Oxidized • Hydrolysis • Disulfide bond mismatch • Racemization • β-elimination • Denaturation, adsorption, aggregation or precipitation
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