From Molecule to Medicine, Faster, Smarter Chemistry
Medicilon Chemistry: From Discovery to Delivery
Overview
Discovery Chemistry: Fueling the First Spark of Innovation
Every great therapy begins with a brilliant idea and robust, smart chemistry to bring it to life. At Medicilon, we offer end-to-end support to accelerate your path from concept to preclinical success, starting with pinpointing and validating biological targets to lay the groundwork for drug discovery.
Core Capabilities
- Compound Library activity screening
- Conventional & AI-augmented drug design
- Structure-activity relationship
- Hit-to-Lead and lead optimization
- Preclinical candidate (PCC) identification
Emerging Modalities
- 300+ linkers
- 150+ E3 ligands (including spiro cycle linkers, CRBN/VHL ligands)
- End-to-end linker-payload synthesis
- DAR optimization
- Linker synthesis and screening (200+ linkers available)
- Payload synthesis (30+ available)
Nucleic Acid drug platform
- Monomer
- Backbone
- Lipid delivery system synthesis
Small molecule GLP-1a synthesis
Custom Synthesis
Preparation of standards, impurities, and metabolites
Synthesis of stable isotope internal standards and deuterated compounds
Core services
Synthetic Chemistry
Synthetic chemistry drives the creation of molecules critical to drug development. With over 1,100 chemists and 440,000 ft2 of laboratory space, Medicilon delivers tailor-made synthetic solutions span from mg to kg scale production, delivering precision, scalability, and flexibility. We excel in both fee-for-service (FFS) and full-time equivalent (FTE) models to align with your project’s complexity and pace.
Medicinal Chemistry
- Intermediates and molecular fragments (pharmalego.com)
- Metabolites & Impurities
- Standards
- Stable isotope internal standards
- Deuterated compounds
Scalable Production
- Reference compound synthesis
- High-purity samples for in vivo studies
- Mg to Kg-scale synthesis (multi-step route development)
Technology Expertise
- Asymmetric synthesis
- Complex molecule (e.g., natural products, PROTACs)
- Complex ring system (b-Lactams, Macrolides, Macrocycles)
- Metal catalyzed coupling reactions (Suzuki, Negishi, Heck, Kumada, Sonogashira, Buchwald-Hartwig, etc.)
- Organoboron/organophosphorus chemistry
- Photoredox reactions and C-H bond functionalization
- Biocatalysis
Synthesis examples
Analytical Chemistry
Quality starts with precision. Reliable analytical support is the foundation of regulatory success and R&D efficiency. Medicilon’s analytical chemistry suite ensures the quality and characterization of compounds throughout the development process.
Equipment & Capabilities
Instrument
Type
- NMR
Bruker, 400MHz
- LC-MS
- Agilent 6120-ELSD/Shimadzu 2020-ELSD/Waters UPLC-Qda
- HPLC
Agilent/Shimadzu/Waters (DAD/VWD/RID/CAD/ELSD)
- UPLC
- Waters ACQUITY UPLC
- Prep-HPLC
Waters 2545-QDa150ml/min/Gilson 281 50ml/min
- GC-HS
- Shimadzu 2010/Agilent 7890B/PE680 (FID Detector /ECD Detector)
- GC-MS
Agilent 5977A/Shimadzu GC-MS 2020
- LC-MS/MS
- Shimadzu 6410
- UPC2
Waters UPCC
- Chiral HPLC
- Shimadzu 20AD/20AT/2030C
- SFC
Waters SFC80/SFC150/SFC300/SFC600
- ICP-MS
- PerkinElmer NexION 1000
- IC
Thermo Scientific Dionex ICS 5000+
- Polarimeter
- Anton Paar MCP5300/MCP300
- Melting Point
METTLER MP70
- KF
- METTLER V30/SC30S
- IR/UV
PE Spectrum TWO/Lambda 365
- PE Spectrum TWO/Lambda 365
- METTLER
- Purity analysis and impurity profiling
- Structural elucidation and confirmation
- Stability testing and degradation studies
- Method development and validation
- eCTD-Ready Reports: IND-supportive, SEND-compliant outputs
- Speed & Integrity: Every 10 chemists supported by 1 full analytical suite
- Risk Mitigation: Full IP protection, EHS oversight, and data security policies
Why choose our chemistry services?
At Medicilon, we’re more than a chemistry service provider – we’re your R&D partner.
Our expert analytical chemists and state-of-the-art instrumentation ensure accurate, regulatory-compliant results at every step.
- Experience: Over 20 years of drug discovery expertise
- Expertise: 1,100+ skilled chemists & Analysts, including dedicated project teams
- Global Reach: Trusted by 1,000+ clients worldwide
- Regulatory-Readiness: Seamless integration from discovery to IND filing
- Flexibility: fully customizable FTE and FFS models tailored to your needs
- Performance: Over 85% success rate in reactions and delivery
From hit discovery to scale-up synthesis and analytical support.
Partner with our chemistry experts to design, synthesize, and validate your next breakthrough compound. With the blend of science, scale, and strategic insight, we are here to accelerate your discovery journey.
